Study type: Medical/biological study (experimental study)

Amyotrophic Lateral Sclerosis (ALS) and extremely-low frequency (ELF) magnetic fields: A study in the SOD-1 transgenic mouse model. med./bio.

Published in: Amyotroph Lateral Scler 2009; 10 (5-6): 370-373

Aim of study (acc. to author)

A transgenic mouse model was used to assess the possible effect of extremely low frequency magnetic fields on the development of amyotrophic lateral sclerosis.

Background/further details

Seven mice per group were exposed to 50 Hz magnetic fields at two intensities before the onset of the clinical signs of amyotrophic lateral sclerosis.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: continuous for 2 hr/day, 5 day/week for 7 weeks

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Exposure duration continuous for 2 hr/day, 5 day/week for 7 weeks
Exposure setup
Exposure source
Setup two sets of Merrit coils; mice placed in a 25 cm x 20 cm plastic cage in the center of the coil system; field uniform within 5 % inside the cage;
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 100 µT effective value measured - -
magnetic flux density 1,000 µT effective value measured - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

The data did not reveal any evidence of a link between extremely low frequency exposure and amyotrophic lateral sclerosis in this transgenic mouse model.

Study character:

Study funded by

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