To study the possible risk due to pulsed electromagnetic fields on rat postnatal neurogenesis in relation to the animal's age and exposure duration.
Newborn (7th postnatal day) and senescent rats (24 months) were examined. Both groups were assigned each to short-term exposure and long-term exposure (=dose). In all groups, post-irradiation changes were assessed after 24 h (acute changes) and after 1-4 weeks (chronic changes).
At least two regions (the subventricular zone and hippocampal dentate gyrus) of the adult brain are responsible for proliferation and migration of neural precursor cells. The subventricular zone functions as the largest region of neurogenesis in the adult brain. Cells born in the subventricular zone migrate via a restricted pathway, called the rostral migratory stream, to the olfactory bulb where they differentiate into local interneurons.
| Exposure | Parameters |
|---|---|
|
Exposure 1:
2.45 GHz
Exposure duration:
4 h/day for 2 days
|
|
|
Exposure 2:
2.45 GHz
Exposure duration:
8 h/day for 3 days
|
|
for further information on the setup see also: Orendac M, Fenik A, Mojzis M, Orendacova J, 2005, "Biological effects of electromagnetic radiation on living systems with respect to the brain.", Psychiatrie suppl. 2:83-85
| Frequency | 2.45 GHz |
|---|---|
| Type | |
| Waveform | |
| Exposure duration | 4 h/day for 2 days |
| Exposure source |
|---|
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| power density | 2.8 mW/cm² | mean | measured | - | - |
| Frequency | 2.45 GHz |
|---|---|
| Type | |
| Waveform | |
| Exposure duration | 8 h/day for 3 days |
| Exposure source |
|
|---|
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| power density | 2.8 mW/cm² | mean | measured | - | - |
Electromagnetic fields induce dose-dependent changes in proliferation within the rostral migratory stream in newborn rats: Short-term exposure induced significant increases in proliferating cell numbers within the rostral migratory stream, while long-term exposure led to a permanent decrease in proliferating cells. Post-exposure changes (acute vs. chronic) were dynamic in new-born rats.
For senescent rats the changes in proliferation activity and the dynamics were negligible.
Electromagnetic fields induced significant age- and dose-dependent changes in proliferating cell numbers within the rostral migratory stream.
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