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Medical/biological study (experimental study)

Purkinje cell number decreases in the adult female rat cerebellum following exposure to 900 MHz electromagnetic field.

Published in: Brain Res 2010; 1356: 95-101

Aim of study (acc. to author)

To study the effect of electromagnetic field exposure on the Purkinje cell number in the cerebellum of adult female rats.
Background/further details: Animals were divided into three groups: control group (n=5), sham exposure group (n=6), and exposure group (n=6).

Endpoint

Exposure

Exposure Parameters
Exposure 1: 900 MHz
Exposure duration: continuous for 1h/day for 28 days
Exposure 1
Main characteristics
Frequency 900 MHz
Type
Exposure duration continuous for 1h/day for 28 days
Exposure setup
Exposure source
Setup rats placed in round plastic tube cages perpendicular to the antenna with a distance of 1 cm between them, the heads positioned in the direction of the antenna; positions of the rats changed daily
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
SAR 0.016 W/kg - - whole body -
SAR 2 W/kg - - brain -
power 2 W peak value - - -
power density density 1 mW/cm² - measured - +/- 0.4 mW/cm²
Reference articles
  • Bas O et al. (2009): 900 MHz electromagnetic field exposure affects qualitative and quantitative features of hippocampal pyramidal cells in the adult female rat.
  • Bas O et al. (2009): Chronic prenatal exposure to the 900 megahertz electromagnetic field induces pyramidal cell loss in the hippocampus of newborn rats.
  • Odaci E et al. (2008): Effects of prenatal exposure to a 900 MHz electromagnetic field on the dentate gyrus of rats: a stereological and histopathological study.
  • Yildiz M et al. (2006): Influence of electromagnetic fields and protective effect of CAPE on bone mineral density in rats.
  • Koylu H et al. (2006): Melatonin modulates 900 Mhz microwave-induced lipid peroxidation changes in rat brain.
  • Koyu A et al. (2005): Effects of 900MHz electromagnetic field on TSH and thyroid hormones in rats.
Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated material:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The data showed that the total number of Purkinje cells in the cerebellum of the exposed rats was significantly lower than those of the control group and sham exposure group. There was no significant difference between the rats' body and brain weights in the three groups.
The authors suggest that long-term exposure to 900 MHz electromagnetic fields leads to decreases of Purkinje cell numbers in the female rat cerebellum.
Study character:

Study funded by

  • not stated/no funding

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