Study type: Medical/biological study (experimental study)

Exposure to an 890-MHz mobile phone-like signal and serum levels of S100B and transthyretin in volunteers. med./bio.

Published in: Toxicol Lett 2009; 189 (1): 63-66

Aim of study (acc. to author)

To study whether exposure to a mobile phone-like signal alters the integrity of the human blood-brain barrier and the blood-cerebrospinal fluid barrier using peripheral markers (transthyretin and S100B protein).

Background/further details

The protein transthyretin served as marker of alterations of the blood-cerebrospinal fluid barrier. Serum S100B protein was used as a putative marker of blood-brain barrier dysfunction.
The aim of the present study was to investigate previous cross-sectional study results (see Soderqvist et al. 2009a and Soderqvist et al. 2009b) further under more controlled conditions. 41 volunteers were exposed for 30 minutes.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 890 MHz
Modulation type: pulsed
Exposure duration: continuous for 30 min
  • SAR: 1 W/kg average over mass (1 g)

Exposure 1

Main characteristics
Frequency 890 MHz
Type
Exposure duration continuous for 30 min
Modulation
Modulation type pulsed
Pulse width 0.577 ms
Repetition frequency 217 Hz
Exposure setup
Exposure source
Distance between exposed object and exposure source 8.5 cm
Parameters
Measurand Value Type Method Mass Remarks
SAR 1 W/kg average over mass - 1 g -

Reference articles

  • Wilen J et al. (2006): Psychophysiological tests and provocation of subjects with mobile phone related symptoms.
  • Huber R et al. (2003): Radio frequency electromagnetic field exposure in humans: Estimation of SAR distribution in the brain, effects on sleep and heart rate.

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • before exposure
  • after exposure

Main outcome of study (acc. to author)

The data showed no statistically significant increase in the serum levels of S100B protein, while for transthyretin a statistically significant increase was found in the final blood sample 60 minutes after the end of the exposure as compared to the prior sample taken immediately after exposure. The clinical significance of this finding, if any, is unknown. Further randomized studies with use of additional more brain specific markers are needed.

Study character:

Study funded by

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