Study type: Medical/biological study (experimental study)

Effects of 915 MHz electromagnetic-field radiation in TEM cell on the blood-brain barrier and neurons in the rat brain. med./bio.

Published in: Radiat Res 2009; 172 (1): 66-73

Aim of study (acc. to author)

The aim of this study was to confirm whether radiofrequency electromagnetic field exposure affected blood-brain barrier permeability and dark neuron expression using the approach of a previous study (Salford et al. 2003).

Background/further details

Several parameters that were not well controlled in the previous study of Salford et al., such as animal age, gender and numbers, were modified to clarify the causality between experimental conditions and results.
The rats were randomly divided into five groups of 16 animals each: Group I was sham-exposed. Group II was exposed at 0.02 W/kg, Group III at 0.2 W/kg, and Group IV at 2.0 W/kg. Group V served as a cage control. Groups I - IV were trained to adapt to confinement in the acrylic box before exposure. Albumin leakage and dark neurons were studied 14 and 50 days after a single 2 h exposure.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 915 MHz
Exposure duration: continuous for 2 h
  • SAR: 0.02 W/kg average over mass (whole body)
  • SAR: 0.2 W/kg average over mass (whole body)
  • SAR: 2 W/kg average over mass (whole body)

Exposure 1

Main characteristics
Frequency 915 MHz
Type
Exposure duration continuous for 2 h
Exposure setup
Exposure source
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
SAR 0.02 W/kg average over mass - whole body -
SAR 0.2 W/kg average over mass - whole body -
SAR 2 W/kg average over mass - whole body -

Reference articles

  • Salford LG et al. (2003): Nerve cell damage in mammalian brain after exposure to microwaves from GSM mobile phones.
  • Salford LG et al. (1994): Permeability of the blood-brain barrier induced by 915 MHz electromagnetic radiation, continuous wave and modulated at 8, 16, 50, and 200 Hz.

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

Neither albumin leakage nor dark neurons were found in any rat brains after radiofrequency electromagnetic field exposure at levels up to 2.0 W/kg whole body SAR, which is 10-fold higher than the SARs Salford et al. used. Therefore, the authors were unable to confirm the results of the previous study of Salford et al. (2003).

Study character:

Study funded by

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