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Medical/biological study (experimental study)

Qualitative Effect on mRNAs of Injury-Associated Proteins by Cell Phone Like Radiation in Rat Facial Nerves.

Published in: Electromagn Biol Med 2009; 28 (4): 383-390

Aim of study (acc. to author)

To check the hypothesis that cell phone irradiation can cause cellular damage to the rat facial nerve (buccal and mandibular branches) leading to increased mRNA transcription of injury-associated proteins.
Background/further details: Six rats were exposed and six rats were sham-exposed (Remark of EMF-Portal editor: The actual number of rats used for each exposure is not specified in this article).

Endpoint

Exposure

Exposure Parameters
Exposure 1: 800 MHz
Exposure duration: 2 times 3 hr / day (with 30 min rest period between exposures), on 7 days/week for 18 weeks
  • SAR: 1.8 W/kg (at 2.2 cm distance)
  • power: 6.3 mW minimum
  • power: 607 mW maximum
Exposure 2: 800 MHz
Exposure duration: 2 times 3 hr / day (with 30 min rest period between exposures), on 7 days/week for 18 weeks
  • SAR: 0.9 W/kg (at 2.2 cm distance)
  • power: 0.01 mW minimum
  • power: 487 mW maximum
Exposure 3: 1.9 GHz
Exposure duration: 2 times 3 hr / day (with 30 min rest period between exposures), on 7 days/week for 18 weeks
  • SAR: 1.18 W/kg (at 2.2 cm distance)
  • power: 0.01 mW minimum
  • power: 335 mW maximum
Exposure 1
Main characteristics
Frequency 800 MHz
Type
Exposure duration 2 times 3 hr / day (with 30 min rest period between exposures), on 7 days/week for 18 weeks
Additional info AMPS mode
Additional info analog
Exposure setup
Exposure source
Distance between exposed object and exposure source 1 cm
Setup cell phone placed bewtween two tubes each holding a rat
Sham exposure A sham exposure was conducted.
Additional info The actual number of rats used for each exposure and their precise position in regard to the mobile phone is not specified in this article.
Parameters
Measurand Value Type Method Mass Remarks
SAR 1.8 W/kg - - - at 2.2 cm distance
power 6.3 mW minimum - - -
power 607 mW maximum - - -
Exposure 2
Main characteristics
Frequency 800 MHz
Type
Exposure duration 2 times 3 hr / day (with 30 min rest period between exposures), on 7 days/week for 18 weeks
Additional info Cell mode
Additional info digital
Exposure setup
Exposure source
Distance between exposed object and exposure source 1 cm
Sham exposure A sham exposure was conducted.
Additional info The actual number of rats used for each exposure and their precise position in regard to the mobile phone is not specified in this article.
Parameters
Measurand Value Type Method Mass Remarks
SAR 0.9 W/kg - - - at 2.2 cm distance
power 0.01 mW minimum - - -
power 487 mW maximum - - -
Exposure 3
Main characteristics
Frequency 1.9 GHz
Type
Exposure duration 2 times 3 hr / day (with 30 min rest period between exposures), on 7 days/week for 18 weeks
Additional info PCS mode
Additional info digital
Exposure setup
Exposure source
Distance between exposed object and exposure source 1 cm
Sham exposure A sham exposure was conducted.
Additional info The actual number of rats used for each exposure and their precise position in regard to the mobile phone is not specified in this article.
Parameters
Measurand Value Type Method Mass Remarks
SAR 1.18 W/kg - - - at 2.2 cm distance
power 0.01 mW minimum - - -
power 335 mW maximum - - -
Reference articles
Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated material:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

All four mRNAs were up-regulated in the exposed group compared to the control group in both nerve sampIes. These differences were statistically significant for all four proteins in the mandibular branch and two for the buccal branch. The mandibular nerve showed a higher and broader level of upregulation than the buccal nerve.
The authors conclude that these upregulations have occurred in the cell phone exposed group because there have been injuries to the surrounding nerve tissue. The authors further conclude if the use of these cell phones continues, there most likely will be permanent damage to these tissues over the years and the likelihood of tumors, cancers, and system failures will potentially increase.
Study character:

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  • Nittby H et al. (2008): Exposure to radiation from global system for mobile communications at 1,800 MHz significantly changes gene expression in rat hippocampus and cortex.
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