Study type: Medical/biological study (experimental study)

Exposure to radiation from global system for mobile communications at 1,800 MHz significantly changes gene expression in rat hippocampus and cortex. med./bio.

Published in: Environmentalist 2008; 28 (4): 458-465

Aim of study (acc. to author)

To study whether exposure to the irradiation from a GSM mobile phone at 1800 MHz has an effect upon the gene expression pattern in rat brain cortex and hippocampus.

Background/further details

8 male rats were assigned to an exposure group (n=4) and a sham exposure group (n=4). The SAR-level for the brain was with 30 mW/kg below the limit for mobile phone emissions set by ICNIRP.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 1,800 MHz
Modulation type: pulsed
Exposure duration: continuous for 6 h

Exposure 1

Main characteristics
Frequency 1,800 MHz
Type
Exposure duration continuous for 6 h
Modulation
Modulation type pulsed
Pulse width 0.57 ms
Repetition frequency 217 Hz
Exposure setup
Exposure source
Chamber 1000 mm x 1100 mm x 2050 mm anechoic chamber made of six demountable plywood board panels laminated with copper foil and covered with absorbing material on the inside; directional antenna placed in the top part of the chamber
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
electric field strength 11.54 V/m - - - -
power density 0.35 W/m² - - - -
SAR 13 mW/kg average over mass calculated whole body -
SAR 30 mW/kg average over mass calculated brain -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The genes did not significantly discriminate between exposed and sham exposed animals. The gene oncology analysis of the differentially expressed genes of both groups revealed four highly significant altered gene categories in both cortex and hippocampus (transmembrane receptor activity, receptor activity, cell surface receptor linked signal transduction and G-protein coupled receptor signaling pathway).
Most of these categories are connected with membrane functions what indicates that the cell membrane is an important target for electromagnetic field effects.

Study character:

Study funded by

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