Study type: Medical/biological study (experimental study)

Stress response in mouse brain after long-term (2 year) exposure to mobile telephone radiofrequency fields using the immediate early gene, c-fos med./bio.

Published in: Pathology 2007; 39 (2): 271-273

Aim of study (acc. to author)

To study the stress response in the mouse brain after repeated, polonged (2 years) exposure using c-fos.

Background/further details

Archival mouse brains from a previous study on tumour (lymphoma) development were used (see publication 9121). The authors also used these brains for another study on blood-brain barrier permeability (see publication 9247).



Exposure Parameters
Exposure 1: 900 MHz
Modulation type: pulsed
Exposure duration: repeated daily exposure, 60 min/day, 5 days/week, for 104 weeks

Exposure 1

Main characteristics
Frequency 900 MHz
Exposure duration repeated daily exposure, 60 min/day, 5 days/week, for 104 weeks
Modulation type pulsed
Pulse width 0.6 ms
Repetition frequency 217 Hz
Additional info

similar to GSM

Exposure setup
Exposure source
Setup The Ferris-wheel exposure system consisted of a cylindrical parallel plate with mice restrained in clear Perspex tubes arranged radially around a dipole antenna. A forced air supply was maintained through the cylinders to prevent heat build-up, and there was no rise in core body temperature.
Sham exposure A sham exposure was conducted.
Additional info A freely moving cage control group was also included.
Measurand Value Type Method Mass Remarks
SAR 4 W/kg - - - -

Reference articles

  • Faraone A et al. (2006): Radiofrequency dosimetry for the Ferris-wheel mouse exposure system
  • Finnie JW (2005): Expression of the immediate early gene, c-fos, in mouse brain after acute global system for mobile communication microwave exposure

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

Prolonged exposure to mobile phone radiofrequency fields did not produce a measurable stress response in the brain using c-fos immunohistochemistry.

Study character:

Study funded by

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