研究のタイプ: 医学/生物学の研究 (experimental study)

[携帯電話の無線周波電磁界に急性(60分間)及び長期(2年間)ばく露したマウスの脳内におけるストレスの尺度としてのミクログリアの活性化] med./bio.

Microglial activation as a measure of stress in mouse brains exposed acutely (60 minutes) and long-term (2 years) to mobile telephone radiofrequency fields.

掲載誌: Pathology 2010; 42 (2): 151-154

この研究は、マウス脳のミクログリア活性化に対する携帯電話無線周波RF磁界の急性又は長期ばく露の影響を調べた。携帯電話の遠方電磁界への全身ばく露SAR=4 W/kg)を、急性ばく露実験は60分間ばく露1回、長期ばく露実験は1日60分間、1週に5日連続、104週間とした。両実験とも、ばく露群(n=10)、擬似ばく露群(n=10)、ケージ対照群(n=10)で行い、ミクログリア活性化のポジティブコントロールには麻酔下で刺傷を与えた。この結果、急性ばく露・長期ばく露のどちらでも、ミクログリア特異的カルシウム結合タンパク質Iba1の発現が、擬似ばく露群、ケージ対照群に比べて上昇することはなかった、と報告している。

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研究目的(著者による)

To study whether acute (60 min) or long-term (five days per week, 104 weeks) exposure of the mouse brain to mobile phone radiofrequency fields produces activation of microglia, which normally respond rapidly to any change in their microenvironment.

詳細情報

Microglia is considered as a specialised form in the central nervous system. In response to a variety of insults, microglia adopts an activated phenotype. Microglia activation plays a pivotal role in the initiation and progression of several neurodegenerative diseases.
30 mice were divided into three groups: 1) exposure group (n=10; remark of EMF-Portal editor: number of animals (distribution) in the acute and long-term exposure group unclear), 2) sham exposure group (n=10) and 3) cage control (n=10). Positive controls were also included (stab wound treatment).

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 900 MHz
Modulation type: pulsed
ばく露時間: continuous for 60 min
acute exposure
ばく露2: 900 MHz
Modulation type: pulsed
ばく露時間: continuous for 5 days/week for 104 weeks
long-term exposure

ばく露1

主たる特性
周波数 900 MHz
タイプ
  • electromagnetic field
特性
  • far field
ばく露時間 continuous for 60 min
Additional information acute exposure
Modulation
Modulation type pulsed
Pulse width 0.6 ms
Repetition frequency 217 Hz
Additional information

GMS like field

ばく露装置
ばく露の発生源/構造
ばく露装置の詳細 mice in perspex tubes arranged radially around the dipole antenna
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
SAR 4 W/kg - - whole body -

ばく露2

主たる特性
周波数 900 MHz
タイプ
  • electromagnetic field
特性
  • far field
ばく露時間 continuous for 5 days/week for 104 weeks
Additional information long-term exposure
Modulation
Modulation type pulsed
Pulse width 0.6 ms
Repetition frequency 217 Hz
Additional information

GMS like field

ばく露装置
ばく露の発生源/構造
  • E1と同じ装置
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
SAR 4 W/kg - - whole body -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

There was no increase in microglial Iba1 expression in brains of short or long-term exposed mice compared to the controls (sham exposed or cage control), while substantial microglial activation occurred in damaged positive control neural tissue.
The authors conclude that an acute or longer duration exposure of murine brains to mobile phone radiofrequency electromagnetic fields did not produce any microglial activation detectable by Iba1 immunostaining.

研究の種別:

研究助成

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