この研究は、マウス脳のミクログリア活性化に対する携帯電話無線周波（RF）磁界の急性又は長期ばく露の影響を調べた。携帯電話の遠方電磁界への全身ばく露（SAR=4 W/kg）を、急性ばく露実験は60分間ばく露1回、長期ばく露実験は1日60分間、1週に5日連続、104週間とした。両実験とも、ばく露群（n=10）、擬似ばく露群（n=10）、ケージ対照群（n=10）で行い、ミクログリア活性化のポジティブコントロールには麻酔下で刺傷を与えた。この結果、急性ばく露・長期ばく露のどちらでも、ミクログリア特異的カルシウム結合タンパク質Iba1の発現が、擬似ばく露群、ケージ対照群に比べて上昇することはなかった、と報告している。
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To study whether acute (60 min) or long-term (five days per week, 104 weeks) exposure of the mouse brain to mobile phone radiofrequency fields produces activation of microglia, which normally respond rapidly to any change in their microenvironment.
Microglia is considered as a specialised form in the central nervous system. In response to a variety of insults, microglia adopts an activated phenotype. Microglia activation plays a pivotal role in the initiation and progression of several neurodegenerative diseases.
30 mice were divided into three groups: 1) exposure group (n=10; remark of EMF-Portal editor: number of animals (distribution) in the acute and long-term exposure group unclear), 2) sham exposure group (n=10) and 3) cage control (n=10). Positive controls were also included (stab wound treatment).
| 周波数 | 900 MHz |
|---|---|
| タイプ |
|
| 特性 |
|
| ばく露時間 | continuous for 60 min |
| Additional information | acute exposure |
| Modulation type | pulsed |
|---|---|
| Pulse width | 0.6 ms |
| Repetition frequency | 217 Hz |
| Additional information |
GMS like field |
| ばく露の発生源／構造 | |
|---|---|
| ばく露装置の詳細 | mice in perspex tubes arranged radially around the dipole antenna |
| Sham exposure | A sham exposure was conducted. |
| 測定量 | 値 | 種別 | Method | Mass | 備考 |
|---|---|---|---|---|---|
| SAR | 4 W/kg | - | - | whole body | - |
| 周波数 | 900 MHz |
|---|---|
| タイプ |
|
| 特性 |
|
| ばく露時間 | continuous for 5 days/week for 104 weeks |
| Additional information | long-term exposure |
| Modulation type | pulsed |
|---|---|
| Pulse width | 0.6 ms |
| Repetition frequency | 217 Hz |
| Additional information |
GMS like field |
| ばく露の発生源／構造 |
|
|---|---|
| Sham exposure | A sham exposure was conducted. |
| 測定量 | 値 | 種別 | Method | Mass | 備考 |
|---|---|---|---|---|---|
| SAR | 4 W/kg | - | - | whole body | - |
There was no increase in microglial Iba1 expression in brains of short or long-term exposed mice compared to the controls (sham exposed or cage control), while substantial microglial activation occurred in damaged positive control neural tissue.
The authors conclude that an acute or longer duration exposure of murine brains to mobile phone radiofrequency electromagnetic fields did not produce any microglial activation detectable by Iba1 immunostaining.
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