Study type: Epidemiological study (observational study)

Mobile Phone Use and the Risk for Malignant Brain Tumors: A Case-Control Study on Deceased Cases and Controls. epidem.

Published in: Neuroepidemiology 2010; 35 (2): 109-114

Aim of study (acc. to author)

A case-control study on deceased cases and controls was conducted in Sweden to investigate the association between the use of mobile phones or cordless phones and the risk for malignant brain tumors.

Further details

The cases analyzed in the present study were excluded in the publication of Hardell et al 2006 because they died before they could be interviewed about their mobile phone use.
Exposure of the cases and controls was assessed by a questionnaire sent to the next-of-kin (wife or husband, child, parent, sibling or other relative).

Endpoint/type of risk estimation

Type of risk estimation: (odds ratio (OR))

Exposure

Assessment

Exposure groups

Group Description
Reference group 1 unexposed
Group 2 analog mobile phone use > 1 to 5 years
Group 3 analog mobile phone use > 5 to 10 years
Group 4 analog mobile phone use > 10 years
Group 5 analog mobile phone use > 1 year (group 2+3+4)
Group 6 analog mobile phone use ≤ 149 h, > 1 to 5 years
Group 7 analog mobile phone use ≤ 149 h, > 5 to 10 years
Group 8 analog mobile phone use ≤ 149 h, >10 years
Group 9 analog mobile phone use ≤ 149 h, >1 year
Group 10 analog mobile phone use > 149 h, > 1 to 5 years
Group 11 analog mobile phone use > 149 h, > 5 to 10 years
Group 12 analog mobile phone use > 149 h, >10 years
Group 13 analog mobile phone use > 149 h, >1 year
Group 14 digital mobile phone use > 1 to 5 years
Group 15 digital mobile phone use > 5 to 10 years
Group 16 digital mobile phone use >10 years
Group 17 digital mobile phone use >1 year
Group 18 digital mobile phone use ≤ 183 h, > 1 to 5 years
Group 19 digital mobile phone use ≤ 183 h, > 5 to 10 years
Group 20 digital mobile phone use ≤ 183 h, >10 years
Group 21 digital mobile phone use ≤ 183 h, >1 year
Group 22 digital mobile phone use > 183 h, > 1 to 5 years
Group 23 digital mobile phone use > 183 h, > 5 to 10 years
Group 24 digital mobile phone use > 183 h, >10 years
Group 25 digital mobile phone use > 183 h, >1 year
Group 26 mobile phone (analog and digital) use > 1 to 5 years
Group 27 mobile phone use > 5 to 10 years
Group 28 mobile phone use >10 years
Group 29 mobile phone use >1 year
Group 30 mobile phone use ≤ 176 h, > 1 to 5 years
Group 31 mobile phone use ≤ 176 h, > 5 to 10 years
Group 32 mobile phone use ≤ 176 h, >10 years
Group 33 mobile phone use ≤ 176 h, >1 year
Group 34 mobile phone use > 176 h, > 1 to 5 years
Group 35 mobile phone use > 176 h, > 5 to 10 years
Group 36 mobile phone use > 176 h, >10 years
Group 37 mobile phone use > 176 h, >1 year
Group 38 cordless phone use > 1 to 5 years
Group 39 cordless phone use > 5 to 10 years
Group 40 cordless phone use >10 years
Group 41 cordless phone use >1 year
Group 42 cordless phone use ≤ 548 h, > 1 to 5 years
Group 43 cordless phone use ≤ 548 h, > 5 to 10 years
Group 44 cordless phone use ≤ 548 h, >10 years
Group 45 cordless phone use ≤ 548 h, >1 year
Group 46 cordless phone use > 548 h, > 1 to 5 years
Group 47 cordless phone use > 548 h, > 5 to 10 years
Group 48 cordless phone use > 548 h, >10 years
Group 49 cordless phone use > 548 h, >1 year
Group 50 mobile + cordless phone use > 1 to 5 years
Group 51 mobile + cordless phone use > 5 to 10 years
Group 52 mobile + cordless phone use >10 years
Group 53 mobile + cordless phone use >1 year
Group 54 mobile + cordless phone use ≤ 410 h, > 1 to 5 years
Group 55 mobile + cordless phone use ≤ 410 h, > 5 to 10 years
Group 56 mobile + cordless phone use ≤ 410 h, >10 years
Group 57 mobile + cordless phone use ≤ 410 h, >1 year
Group 58 mobile + cordless phone use > 410 h, > 1 to 5 years
Group 59 mobile + cordless phone use > 410 h, > 5 to 10 years
Group 60 mobile + cordless phone use > 410 h, >10 years
Group 61 mobile + cordless phone use > 410 h, >1 year
Group 62 analog mobile phone, cumulative lifetime use: 1 - 1,000 h
Group 63 analog mobile phone, cumulative lifetime use: 1,001 - 2,000 h
Group 64 analog mobile phone, cumulative lifetime use: > 2,000 h
Group 65 digital mobile phone, cumulative lifetime use: 1 - 1,000 h
Group 66 digital mobile phone, cumulative lifetime use: 1,001 - 2,000 h
Group 67 digital mobile phone, cumulative lifetime use: > 2,000 h
Group 68 mobile phone, cumulative lifetime use: 1 - 1,000 h
Group 69 mobile phone, cumulative lifetime use: 1,001 - 2,000 h
Group 70 mobile phone, cumulative lifetime use: > 2,000 h
Group 71 cordless phone, cumulative lifetime use: 1 - 1,000 h
Group 72 cordless phone, cumulative lifetime use: 1,001 - 2,000 h
Group 73 cordless phone, cumulative lifetime use: > 2,000 h
Group 74 mobile + cordless phone, cumulative lifetime use: 1 - 1,000 h
Group 75 mobile + cordless phone, cumulative lifetime use: 1,001 - 2,000 h
Group 76 mobile + cordless phone, cumulative lifetime use: > 2,000 h

Population

Case group

Control group

Study size

Cases Controls
Participants 346 619
Participation rate 75 % 67 %
Statistical analysis method: (adjustment: )

Conclusion (acc. to author)

A statistically significant increased risk of malignant brain tumors was observed among the group of diseased mobile phone users (only analog mobile phone in group 4, analog and digital mobile phone in group 28, digital mobile phone in group 16 (only 2 cases and no controls, calculation of OR not possible), highest in the group with mobile phone use of more than 176 h and a latency time of more than 10 years (group 36). No statistically significant increased risk was observed for cordless phones (groups 38-49).
The authors concluded that the investigation confirmed previous results of an association between mobile phone use and malignant brain tumors.

Limitations (acc. to author)

Only few subjects have used digital mobile phones for more than 10 years.

Study funded by

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