Study type: Medical/biological study (experimental study)

Reactive Oxygen Species Formation and Apoptosis in Human Peripheral Blood Mononuclear Cell Induced by 900 MHz Mobile Phone Radiation. med./bio.

Published in: Oxid Med Cell Longev 2012: 740280

Aim of study (acc. to author)

To study the extent of reactive oxygen species formation and oxidative DNA damage as well as cell apoptosis caused by radiofrequency electromagnetic fields on human peripheral blood mononuclear cells.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 900 MHz
Exposure duration: continuous for 1 h, 2 h, 4 h, 6 h or 8 h

Exposure 1

Main characteristics
Frequency 900 MHz
Type
Exposure duration continuous for 1 h, 2 h, 4 h, 6 h or 8 h
Modulation
Modulation type cf. additional info
Additional info

GSM

Exposure setup
Exposure source
  • RF emitter
Setup cells were exposed in culture plates
Parameters
Measurand Value Type Method Mass Remarks
SAR 0.43 W/kg - estimated - -
electric field strength 43.42 V/m - - - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The data showed that apoptosis could be induced in human peripheral blood mononuclear cells by exposure of 900 MHz radiofrequency electromagnetic fields (SAR 0.4 W/kg) when the exposure lasted longer than two hours. The apoptosis was induced through the mitochondrial pathway and mediated by reactive oxygen species (increase after 2-6 h exposure) and caspase-3 (increase after 4-6 h exposure), and by a decreased mitochondrial membrane potential (after 2-6 h exposure). The formation of reactive oxygen species was triggered by the conformation disturbance of lipids, protein, and DNA induced by the exposure.

Study character:

Study funded by

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