Study type: Medical/biological study (observational study)

Cell phone use is associated with an inflammatory cytokine profile of parotid gland saliva. med./bio.

Published in: J Oral Pathol Med 2016; 45 (9): 682-686

Aim of study (acc. to author)

The effects of mobile phone usage on inflammatory cytokine expression in the saliva produced by the parotid glands should be investigated.

Background/further details

Saliva samples from both parotid glands were collected from 83 healthy volunteer students (1 subject was excluded from analysis) and the cytokine expression profile was correlated with the self-reported mobile phone use. Self-reported parameters for usage were: cumulative monthly cell phone use (up to 200 min (n=48) or more than 200 minutes (n=34)), period of cell phone use (up to 10 years (n=47) or more than 10 years (n=35)) and laterality of use (right (n=75) or left ear (n=7)).

Endpoint

Exposure

Exposure Parameters
Exposure 1:
Exposure duration: up to 200 minutes per month for up to 10 years
-
Exposure 2:
Exposure duration: up to 200 minutes per month for more than 10 years
-
Exposure 3:
Exposure duration: more than 200 minutes per month for up to 10 years
-
Exposure 4:
Exposure duration: more than 200 minutes per month for more than 10 years
-

Exposure 1

Main characteristics
Frequency
Type
Exposure duration up to 200 minutes per month for up to 10 years
Exposure setup
Exposure source
Setup self-reported exposure parameters (see background)
Parameters

No parameters are specified for this exposure.

Exposure 2

Main characteristics
Frequency
Type
Exposure duration up to 200 minutes per month for more than 10 years
Exposure setup
Exposure source
Parameters

No parameters are specified for this exposure.

Exposure 3

Main characteristics
Frequency
Type
Exposure duration more than 200 minutes per month for up to 10 years
Exposure setup
Exposure source
Parameters

No parameters are specified for this exposure.

Exposure 4

Main characteristics
Frequency
Type
Exposure duration more than 200 minutes per month for more than 10 years
Exposure setup
Exposure source
Parameters

No parameters are specified for this exposure.

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

Protein expression of interleukin-10 was significantly decreased and protein expression of interleukin-1β and the total protein concentration were significantly increased in samples from the ipsilateral parotid gland (i.e., from the head side of prefered mobile usage) compared to the contralateral gland. Subjects who used mobile phones for more than 10 years presented a significantly higher decrease in interleukin-10 levels in the ipsilateral samples compared to ipsilateral samples from subjects who used their mobile phone for up to 10 years.
All other parameters did not show any significant correlations with the mobile phone usage.
The authors conclude that mobile phone usage might increase the expression of inflammatory cytokines interleukin-1β and interleukin-10 in the saliva produced by the ipsilateral parotid gland. The causes for these effects are unknown but may be related to heat production.

Study character:

Study funded by

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