研究のタイプ: 医学/生物学の研究 (observational study)

[高電圧電力線にばく露した労働者の健康に対する緑茶ポリフェノール補助食品の効果] med./bio.

Effects of dietary green tea polyphenol supplementation on the health of workers exposed to high-voltage power lines.

掲載誌: Environ Toxicol Pharmacol 2016; 46: 183-187

この研究は、超低周波電磁界(ELF-EMFs)へのばく露による酸化ストレス指標(尿中の8-ソプラスタンおよび8-OHdG)の変化、およびELF-EMFsに誘導された酸化ストレスへの緑茶ポリフェノールサプリメント(GTPS)の保護効果の可能性をボランティア実験で調べた。110-420kV電力線からのELF-EMFsばく露有りおよび無しの労働者(合計n=867)をそれぞれ無作為にGTPS摂取群とプラセボ摂取群に割り当てた。その結果、ELF-EMFsばく露有りの労働者群では尿中の8-ソプラスタンおよび8-OHdGが有意に上昇していたが、GTPSの12ヵ月間投与後にこの上昇は消失した;GTPSの投与停止から3ヵ月後にGTPSの酸化ストレス保護作用は見られなかった、と報告している。

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研究目的(著者による)

The effects of occupational exposure to high-voltage power lines (50/60 Hz) on oxidative stress and oxidative DNA damage in workers urine and the protective effect of green tea polyphenols should be investigated.

詳細情報

Several studies have found a protective effect of green tea polyphenols against oxidative damage, what should now be tested in electro-magnetic field exposure.
Participants consisted of substation workers with occupational exposure to 110-420 kV lines as exposed subjects and subjects who work in administration as non-exposed subjects. Both groups were randomly divided into two subgroups: placebo and green tea polyphenol supplementation (GTPS) for 12 months. The capsules were orally administered twice daily and contained 250 mg of green tea extract without caffeine. The following groups were used in the study: 1) occupational exposure and placebo (n=67), 2) no exposure and placebo (n=54), 3) occupational exposure and GTPS (n=123), 4) no exposure and GTPS (n=77).

影響評価項目

ばく露

ばく露 パラメータ
ばく露1:
ばく露時間: approximately 8 hours/day
-

ばく露1

主たる特性
周波数
タイプ
  • electric field
  • magnetic field
ばく露時間 approximately 8 hours/day
ばく露装置
ばく露の発生源/構造
  • power lines
ばく露装置の詳細 working in a 110-420 kV substation
パラメータ

No parameters are specified for this exposure.

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

Prior to the GTPS treatment, subjects from the exposure groups (groups 1 and 3) showed significantly higher levels of oxidative stress and oxidative DNA damage compared to the control groups (groups 2 and 4). After 12 months of GTPS treatment (group 3), the values were significantly reduced compared to the initial value, while there were no significant changes observed in the placebo group (group 1).
3 months after the end of GTPS treatment, oxidative stress and DNA damage were again increased to the initial levels before GTPS treatment in group 3, which revealed the reversible effect of GTPS.
The authors conclude that occupational exposure to high-voltage power lines (50/60 Hz) might induce oxidative stress and oxidative DNA damage and that green tea polyphenol supplementation might protect against these effects.

研究の種別:

研究助成

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