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Medical/biological study (experimental study)

Long-term exposure to a continuous 900 MHz electromagnetic field disrupts cerebellar morphology in young adult male rats.

Published in: Biotech Histochem 2017; 92 (5): 324-330

Aim of study (acc. to author)

To investigate the effect of a 900 MHz-electromagnetic field on potential histological changes in the cerebellum of adolescent rats .
Background/further details: Eighteen male rats (21 old days old) were divided in three groups (n=6 per group): 1) cage control, 2) sham exposure, and 3) exposure group.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 900 MHz
Exposure duration: 1 hour/day for 25 consecutive days
Exposure 1
Main characteristics
Frequency 900 MHz
Type
Exposure duration 1 hour/day for 25 consecutive days
Exposure setup
Exposure source
Setup EMF cage (42 x 30 x 50 cm3) in which rats were allowed to move around freely during exposure/sham exposure; antenna (15 cm long) was mounted 39 cm above the EMF cage floor using an insulating wooden rod; signal was transmitted from the oscillator by a coaxial cable to the antenna; no statistically significant difference in the temperature was observed between exposure (21.4 ± 1.7°C) and sham exposure (21.7 ± 1.7°C)
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
SAR 0.01 W/kg - calculated whole body -
electric field strength 6.8 V/m mean measured - beneath the empty EMF cage
electric field strength 11.9 V/m mean measured - within the empty EMF cage
electric field strength 4.5 V/m mean measured - beneath the EMF cage with
electric field strength 13.4 V/m mean measured - within the EMF cage with rats
Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated material:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The number of Purkinje cells was significantly reduced in exposed rats compared to sham exposed and cage control rats. Furthermore, in cerebellums from exposed rats, the arrangement of Purkinje cells was altered and pathological changes were observed (more intense staining of neuron cytoplasm) while the morphology in cerebellums from sham exposed rats and those from the cage control appeared normal.
The authors conclude that a 900 MHz-electromagnetic field could induce histological changes in the cerebellum of adolescent rats.
Study character:

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  • Kerimoglu G et al. (2016): Pernicious effects of long-term, continuous 900-MHz electromagnetic field throughout adolescence on hippocampus morphology, biochemistry and pyramidal neuron numbers in 60-day-old Sprague Dawley male rats.
  • Sonmez OF et al. (2010): Purkinje cell number decreases in the adult female rat cerebellum following exposure to 900 MHz electromagnetic field.
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  • Kumlin T et al. (2007): Mobile phone radiation and the developing brain: behavioral and morphological effects in juvenile rats.
  • Albert EN et al. (1981): Effect of nonionizing radiation on the Purkinje cells of the rat cerebellum.