Study type: Medical/biological study (experimental study)

Effect of nonionizing radiation on the Purkinje cells of the rat cerebellum. med./bio.

Published in: Bioelectromagnetics 1981; 2 (3): 247-257

Aim of study (acc. to author)

To study the effect of microwave exposure on the density of Purkinje cells in developing rat brains in three different experiments: 1) rats and their offspring were exposed to 100 MHz (CW) electromagnetic irradiation (SAR 2.77 mW/g) for 4 h/day for 97 days; 2) pregnant rats were exposed daily from 17 to 21 days of gestation with 2450 MHz (CW) microwaves (SAR 2 mW/g) for 21 h/day; 3) 6-day-old rat pups were exposed 7 h/day for five days with 2450 MHz irradiation at 10 mW/cm².

Endpoint

Exposure

Exposure Parameters
Exposure 1: 2.45 GHz
Modulation type: CW
Exposure duration: 21 h/day for 5 days
  • SAR: 2 mW/g mean (cf. remarks) (0.5 W/kg min value; 6 W/kg max value)
  • power density: 100 W/m² mean (animal might have recieved 40 W/m² min value; 300 W/m² max value)
Exposure 2: 2.45 GHz
Modulation type: CW
Exposure duration: 7 h/day for 5 days
Exposure 3: 100 MHz
Modulation type: CW
Exposure duration: pregnant rats starting on the sixth day of gestation throughtout their pregnancy period were exposed; their off-spings were exposed 4 h/day for 97 days

General information

Pregnant rats were exposed.

Exposure 1

Main characteristics
Frequency 2.45 GHz
Type
Waveform
Exposure duration 21 h/day for 5 days
Modulation
Modulation type CW
Exposure setup
Exposure source
Distance between exposed object and exposure source 2.08 m
Chamber plexiglas containers with removable polystyrene grids/ 19 x 11.4 x 7.6 cm
Parameters
Measurand Value Type Method Mass Remarks
SAR 2 mW/g mean calculated cf. remarks 0.5 W/kg min value; 6 W/kg max value
power density 100 W/m² mean measured - animal might have recieved 40 W/m² min value; 300 W/m² max value

Exposure 2

Main characteristics
Frequency 2.45 GHz
Type
Waveform
Exposure duration 7 h/day for 5 days
Modulation
Modulation type CW
Exposure setup
Exposure source
Distance between exposed object and exposure source 2.08 m
Chamber plexiglas containers with removable polystyrene grids/ 19 x 11.4 x 7.6 cm
Parameters
Measurand Value Type Method Mass Remarks
power density 100 W/m² unspecified unspecified - -

Exposure 3

Main characteristics
Frequency 100 MHz
Type
Waveform
Exposure duration pregnant rats starting on the sixth day of gestation throughtout their pregnancy period were exposed; their off-spings were exposed 4 h/day for 97 days
Additional info Ref.Article: Smialowicz RI, Berman E, Bwisian SJ, Kim JB, Liddle CG, Reiter LW, Weil CM (1979): Chronic exposure of rats to 100 MHz (CW) radiofrequency radiation: Assesment of biological effects . URSI Bioelectromagnetics Symposium. Abstracts, p 397.
Modulation
Modulation type CW
Exposure setup
Exposure source
  • not specified
Additional info *
Parameters
Measurand Value Type Method Mass Remarks
SAR 2.77 mW/g unspecified unspecified - -
power density 460 W/m² unspecified measured - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The results showed a significant and irreversible decrease of Purkinje cell density in rats irradiated during fetal or fetal and early postnatal life. In rats exposed postnatally, and euthanized immediately after exposure, significant decrease in the relative number of Purkinje cells was apparent. However, restoration apparently occured after forty days of recovery.

Study character:

Study funded by

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