Study type: Medical/biological study (experimental study)

Biochemical and histological studies on adverse effects of mobile phone radiation on rat's brain. med./bio.

Published in: J Chem Neuroanat 2016; 78: 10-19

Aim of study (acc. to author)

The effects of exposure of rats to a 1800 MHz electromagnetic field on oxidative stress, DNA damage and histology in the brain should be investigated.

Background/further details

40 male rats were divided into two groups (n=20 each): 1) exposure group and 2) control group.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 1,800 MHz
Exposure duration: continuous for 120 min/day for three months

Exposure 1

Main characteristics
Frequency 1,800 MHz
Type
Exposure duration continuous for 120 min/day for three months
Exposure setup
Exposure source
Distance between measurement device and exposure object 5 cm
Setup each group was placed in four cages (five rats per cage); one mobile phone was placed in the bottom of each cage at the center under a wire mesh to give maximum exposure near the brain.
Additional info the control group was placed in four cages (five rats per cage) in a separate room away from any mobile phones
Parameters
Measurand Value Type Method Mass Remarks
SAR 0.6 W/kg - cf. remarks - according to the user guide of the mobile phone
power density 0.87 mW/cm² - estimated - via radiofrequency meter

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

Oxidative stress was significantly increased in hippocampus and cerebellum samples from exposed animals compared to the control group, while antioxidant parameters (content of reduced glutathione, enzyme activities of glutathione peroxidase and superoxide dismutase) were significantly decreased.
The amount of cyclooxygenase-2 was significantly increased in hippocampus and cerebellum samples from exposed animals compared to the control group, indicating increased neural damage.
DNA fragmentation was also significantly increased in hippocampus and cerebellum samples of the exposure group compared to the control group.
Histological and ultrastructural analysis showed degenerative changes in hippocampal pyramidal cells and dark cells and cerebellar Purkinje cells with vascular congestion in the exposure group and normal appearance in the control group.
The authors conclude that exposure of rats to a 1800 MHz electromagnetic field might lead to oxidative stress, DNA damage and histological changes in the brain.

Study character:

Study funded by

Comments on this article

Related articles