Study type: Medical/biological study (experimental study)

Power frequency fields promote cell differentiation coincident with an increase in transforming growth factor-beta(1) expression med./bio.

By: Aaron RK, Ciombor DM, Keeping H, Wang S, Capuano A, Polk C
Published in: Bioelectromagnetics 1999; 20 (7): 453-458
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Aim of study (acc. to editor)

This in vivo study was performed to investigate the effects of low frequency electromagnetic field similar to power frquency line on bone tissue cell differentiation in rats.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 60 Hz
Exposure duration: 7-11 h/day for 8 days

Exposure 1

Main characteristics
Frequency 60 Hz
Type
Exposure duration 7-11 h/day for 8 days
Exposure setup
Exposure source
Setup 16 coils arranged in 2 sets as 4-coil Merrit configuration
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
electric field strength 30 V/m - estimated - induced field at 0.1mT 60Hz
magnetic flux density 0.01 mT minimum measured - -
magnetic flux density 0.1 mT maximum measured - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The exposure to low frequency electromagnetic field compared to sham exposure showed no significant changes in cell number or calcium content.
Significant increase in chondrogenesis were found at exposure to 0.07 and 0.1 mTconfirmed by increased expression of mRNA for the extracellular matrix proteins, proteoglycan and type II collagen. Additionally TGF-beta1 mRNA and protein expression were statistically significant increased.

Study character:

Study funded by

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