Study type: Medical/biological study (experimental study)

Investigation into the effects of static and electric fields on bone healing process: An experimental tibial fracture model study in Wistar-Albino male rats. med./bio.

Published in: North Clin Istanb 2021; 8 (1): 8-14

Aim of study (acc. to author)

The effects of exposure to a static electric field or 50 Hz electric field on bone healing in rats should be investigated.

Background/further details

A total of 45 male rats were randomly divided into the following groups (n=15 each): 1) exposure to a 50 Hz electric field, 2) exposure to a static electric field, 3) control group. A manual fracture was performed in the left tibia diaphysis of all rats, and fractures were fixed using circular plaster over the knee. As a result of excluded or deceased rats, not all rats could be examined in the different tests, however, at least 12 rats/group were analyzed.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: 30 minutes/day on 5 days/week for 8 weeks
Exposure 2: 0 Hz
Exposure duration: 30 minutes/day on 5 days/week for 8 weeks

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Exposure duration 30 minutes/day on 5 days/week for 8 weeks
Exposure setup
Exposure source
Setup rats were placed in cages between parallel plate capacitors; rats in the control group were kept under the same conditions as the exposure groups, although they were not exposed to an electric field; all experiments were conducted in a certified clean and electromagnetically shielded room
Parameters
Measurand Value Type Method Mass Remarks
electric field strength 6 kV/m minimum measured - -
electric field strength 10 kV/m maximum measured - -

Exposure 2

Main characteristics
Frequency 0 Hz
Type
Exposure duration 30 minutes/day on 5 days/week for 8 weeks
Exposure setup
Exposure source
Parameters
Measurand Value Type Method Mass Remarks
electric field strength 5 kV/m - - - -

Reference articles

  • Aslan A et al. (2012): [Effects Of 50 Hz Electric Field On Bone Mineral Densitiy And Fractures Healing: An Experimental Rat Study].
  • Okudan B et al. (2006): DEXA analysis on the bones of rats exposed in utero and neonatally to static and 50 Hz electric fields.

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

Radiologic, mechanical and histologic scores were lower in group 1 (50 Hz) than in group 2 (static electric field) and the control group. However, the differences were not statistically significant.
The authors concluded that there were no statistically significant effects of exposure to a static electric field or 50 Hz electric field on bone healing in rats.

Study character:

Study funded by

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