Study type: Medical/biological study (experimental study)

The preventive effect on bone loss of 50-Hz, 1-mT electromagnetic field in ovariectomized rats. med. app.

Published in: J Bone Miner Metab 2002; 20 (6): 345-349

Aim of study (acc. to author)

To investigate the preventive effects of an electromagnetic field in osteoporosis occuring after ovariectomy (excision of one or both ovaries).

Background/further details

18 female rats (10 exposed, 8 sham exposed) were examined.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: repeated daily exposure, 4 h/day for 6 weeks

General information

The animals were divided into two groups: the exposed (n=10) and non-exposed control (n= 8) groups.

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Waveform
Exposure duration repeated daily exposure, 4 h/day for 6 weeks
Exposure setup
Exposure source
Setup The rats in the experimental group were housed individually in 24 x 25 x 28 cm³ methacrylate cages placed between two activated coils. The rats in the control group were housed similarly but between the inactive coils.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 1 mT unspecified measured - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The cortical thickness of the tibia was increased in exposed rats. The levels of sodium and potassium in the tibia of exposed rats were significantly increased as well.
Additionally an increased blood alkaline phosphatase level was observed after electromagnetic field exposure.
No significant differences in the levels of calcium, magnesium, lithium, or creatine were found.
These data support the hypothesis that an electromagnetic field may be an effective treatment method for osteoporosis.

Study character:

Study funded by

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