Study type: Medical/biological study (experimental study)

Increase in hypoxanthine-guanine phosphoribosyl transferase gene mutations by exposure to electric field. med./bio.

Published in: Life Sci 2001; 68 (9): 1041-1046

Aim of study (acc. to author)

This study was performed to investigate whether the results of a previous study (see publication 2074) concerning increased hypoxanthine-guanine phosphoribosyl transferase gene mutations were induced by the exposure to magnetic field, electric field or both.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 60 Hz
Exposure duration: 10 h (exposed or sham exposed)

Exposure 1

Main characteristics
Frequency 60 Hz
Type
Waveform
Exposure duration 10 h (exposed or sham exposed)
Exposure setup
Exposure source
Exposure room 15 cm diameter dish
Setup electrodes with plastic holders installed in a dish in CO2 incubator
Additional info for sham exposure, the potential remains at 0 mV.
Parameters
Measurand Value Type Method Mass Remarks
electric field strength 10 V/m maximum measured - -

Reference articles

  • Miyakoshi J et al. (1996): Increase in hypoxanthine-guanine phosphoribosyl transferase gene mutations by exposure to high-density 50-Hz magnetic fields.

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The hypoxanthine-guanine phosphoribosyl transferase mutant frequency by electric field exposure was an approximate 2-fold of that by sham-exposure.
These data suggest that the observed increase in hypoxanthine-guanine phosphoribosyl transferase gene mutations of the previuos study were caused, in part, due to the induced electric field.

Study character:

Study funded by

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