Study type: Medical/biological study (experimental study)

Effect of amplitude-modulated radio frequency radiation on cholinergic system of developing rats. med./bio.

Published in: Brain Res 1993; 601 (1-2): 321-324

Aim of study (acc. to author)

To study the effect of amplitude modulated radiofrequency radiation on central cholinergic system in developing rat brain.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 36.75–147 MHz
Modulation type: AM
Exposure duration: repeated daily exposure, 3 h/day, for 30-35 days
  • SAR: 0.14 W/kg mean (0.1-0.14 W/kg)
Exposure 2: 36.75–147 MHz
Modulation type: AM
Exposure duration: continuous for 20, 40, and 60 min

Exposure 1

Main characteristics
Frequency 36.75–147 MHz
Type
Exposure duration repeated daily exposure, 3 h/day, for 30-35 days
Additional info A frequency of 147 MHz and its sub-harmonics of 73.5 and 36.75 MHz were used.
Modulation
Modulation type AM
Modulation frequency 16–76 Hz
Additional info

Modulation frequencies of 16 and 76 Hz were applied.

Exposure setup
Exposure source
Chamber Plexiglas cages (32 x 10 x 9 cm³) were aerated by small circular holes.
Setup Four rats were kept in a cage, restrained with their long body axis parallel to the electric field.
Sham exposure A sham exposure was conducted.
Additional info One time exposure for up to 3 h was also tested.
Parameters
Measurand Value Type Method Mass Remarks
SAR 0.14 W/kg mean - - 0.1-0.14 W/kg

Exposure 2

Main characteristics
Frequency 36.75–147 MHz
Type
Exposure duration continuous for 20, 40, and 60 min
Additional info A frequency of 147 MHz and its sub-harmonics of 73.5 and 36.75 MHz were used.
Modulation
Modulation type AM
Modulation frequency 16–76 Hz
Additional info

Modulation frequencies of 16 and 76 Hz were applied.

Exposure setup
Exposure source
Setup 160 µg of membrane protein from various groups of exposed and control rats were exposed in vitro in polyallomer tubes to their respective fields.
Parameters
Measurand Value Type Method Mass Remarks
SAR 0.09 W/kg mean - - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

A significant decrease in acetylcholinesterase activity was observed in exposed animals as compared to the control. Decrease in acetylcholinesterase activity was independent of carrier wave frequencies. A short-term irradiation did not have any significant effect on the enzyme activity of acetylcholinesterase.

Study character:

Study funded by

Related articles