研究のタイプ: 医学/生物学の研究 (experimental study)

[発達中のラットのコリン作動系に対する振幅変調無線周波放射の影響] med./bio.

Effect of amplitude-modulated radio frequency radiation on cholinergic system of developing rats.

掲載誌: Brain Res 1993; 601 (1-2): 321-324

この研究は、147 MHz、その低調波73.5 MHz、36.75 MHzのそれぞれの振幅変調電磁界変調周波数16 Hzおよび76 Hz)への長期ばく露(30 - 35日、1日3時間)が、発達中のラットの脳内コリン作動系に影響を与えるか否かを調べた。その結果、ばく露群において、対照群と比較して、アセチルコリンエステラーゼ(AChE)活性の有意な低下が見られた;AChE活性の低下は、搬送周波数には依存しなかった;短期ばく露はAChE活性に有意な影響を与えなかった、と報告している。

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研究目的(著者による)

To study the effect of amplitude modulated radiofrequency radiation on central cholinergic system in developing rat brain.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 36.75–147 MHz
Modulation type: AM
ばく露時間: repeated daily exposure, 3 h/day, for 30-35 days
  • SAR: 0.14 W/kg mean (0.1-0.14 W/kg)
ばく露2: 36.75–147 MHz
Modulation type: AM
ばく露時間: continuous for 20, 40, and 60 min
  • SAR: 0.09 W/kg mean

ばく露1

主たる特性
周波数 36.75–147 MHz
タイプ
  • electromagnetic field
ばく露時間 repeated daily exposure, 3 h/day, for 30-35 days
Additional information A frequency of 147 MHz and its sub-harmonics of 73.5 and 36.75 MHz were used.
Modulation
Modulation type AM
Modulation frequency 16–76 Hz
Additional information

Modulation frequencies of 16 and 76 Hz were applied.

ばく露装置
ばく露の発生源/構造
チャンバの詳細 Plexiglas cages (32 x 10 x 9 cm³) were aerated by small circular holes.
ばく露装置の詳細 Four rats were kept in a cage, restrained with their long body axis parallel to the electric field.
Sham exposure A sham exposure was conducted.
Additional information One time exposure for up to 3 h was also tested.
パラメータ
測定量 種別 Method Mass 備考
SAR 0.14 W/kg mean - - 0.1-0.14 W/kg

ばく露2

主たる特性
周波数 36.75–147 MHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 20, 40, and 60 min
Additional information A frequency of 147 MHz and its sub-harmonics of 73.5 and 36.75 MHz were used.
Modulation
Modulation type AM
Modulation frequency 16–76 Hz
Additional information

Modulation frequencies of 16 and 76 Hz were applied.

ばく露装置
ばく露の発生源/構造
ばく露装置の詳細 160 µg of membrane protein from various groups of exposed and control rats were exposed in vitro in polyallomer tubes to their respective fields.
パラメータ
測定量 種別 Method Mass 備考
SAR 0.09 W/kg mean - - -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

A significant decrease in acetylcholinesterase activity was observed in exposed animals as compared to the control. Decrease in acetylcholinesterase activity was independent of carrier wave frequencies. A short-term irradiation did not have any significant effect on the enzyme activity of acetylcholinesterase.

研究の種別:

研究助成

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