Study type: Medical/biological study (observational study)

Comparison of chromosome aberration and micronucleus induction in human lymphocytes after occupational exposure to vinyl chloride monomer and microwave radiation. med./bio.

Published in: Period Biol 1990; 92 (4): 411-416

Aim of study (acc. to author)

To compare the results of the lymphocyte micronucleus test and the chromosome aberration assay from subjects exposed to vinyl chloride monomer (VCM) or to microwave radiation. Blood samples of workers from a radar station service and from the polyvinylchloride industry were investigated.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 200 kHz–26 GHz
Exposure duration: repeated daily exposure

Exposure 1

Main characteristics
Frequency 200 kHz–26 GHz
Exposure duration repeated daily exposure
Exposure setup
Exposure source
Additional info Occupational exposure of workers at a radar service station.
Parameters
Measurand Value Type Method Mass Remarks
power density 200 W/m² maximum measured - -
power density 10 µW/cm² minimum measured - 50 µW/cm² max value.

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

Both quantitative and qualitative differences between vinyl chlorid monomer (VCM) and microwave radiation in the induction of aberrations and micronuclei were detected. VCM causes quantitatively more chromosome damage but less dicentric and ring chromosomes than microwave exposition. Anaphase bridges are present in the cultured lymphocytes of VCM-exposed persons but they are rarely seen in the lymphocytes of microwave-exposed persons. The number of micronuclei per a certain number of aberrations is much higher in persons exposed to VCM than those exposed to microwaves.

Study character:

Study funded by

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