Study type: Medical/biological study (experimental study)

Ultra high frequency-electromagnetic field irradiation during pregnancy leads to an increase in erythrocytes micronuclei incidence in rat offspring. med./bio.

Published in: Life Sci 2006; 80 (1): 43-50

Aim of study (acc. to author)

This study should investigate in rats whether 1.) radiofrequency electromagnetic fields could induce chromosomal damage in erythocytes of rat offspring whose mothers were exposed during pregnancy and 2.) imbalances in free radical metabolism of rat offspring liver and blood occurs.

Background/further details

The exposure group consisted of six adult pregnant rats (90-110 days old, 200-250 grams) and the control group of four animals.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 834 MHz
Exposure duration: repeated daily exposure, 8.5 h/day, throughout pregnancy

Exposure 1

Main characteristics
Frequency 834 MHz
Type
Exposure duration repeated daily exposure, 8.5 h/day, throughout pregnancy
Additional info vertical polarisation
Exposure setup
Exposure source
Distance between exposed object and exposure source 29.5 cm
Chamber Faraday cage (101.5 x 64 x 38 cm) made of 0.5-cm mesh
Setup The rats were housed in individual Plexiglas cages (40.5 x 33.5 x 17.5 cm) that were placed for exposure 29.5 cm away from the mobile phone antenna in its maximum radiation direction.
Sham exposure A sham exposure was conducted.
Additional info The Faraday cage containing the control animal was kept 40.5 cm away from the cage containing the exposure source. Both cages were placed in a wooden rack, and their places were switched every other day.
Parameters
Measurand Value Type Method Mass Remarks
power 0.6 W peak value - - -
electric field strength 40 V/m - measured - 26.8-40 V/m
magnetic field strength 100 mA/m - measured - 70-100 mA/m
power density 0.4 mW/cm² mean measured - 0.2-0.4 mW/cm²
SAR 1.23 W/kg - calculated - 0.55-1.23 W/kg

Reference articles

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

A statistically significant increase in micronuclei occurrence was observed in the irradiated group.
No significant differences were found in any oxidative parameter of offspring plasma and liver. Additionally, the average number of pups in each litter has not been significantly altered.
These data suggest that radiofrequency electromagnetic field is able to induce a genotoxic response in hematopoietic tissue during the embryogenesis. An imbalance in free radicals does not seem to play an important role in its genesis.

Study character:

Study funded by

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