Study type: Medical/biological study (experimental study)

DNA damage in human leukocytes after acute in vitro exposure to a 1.9 GHz pulse-modulated radiofrequency field. med./bio.

Published in: Radiat Res 2002; 158 (4): 534-537

Aim of study (acc. to author)

To evaluate whether an acute (2 h) exposure to a 1.9 GHz pulse-modulated radiofrequency field, similar in waveform envelope to the output of time-division-multiple-access (TDMA) cellular phones, could elicit primary DNA damage and/or induce micronucleus formation in cultured human leukocytes.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 1.9 GHz
Modulation type: pulsed
Exposure duration: continuous for 2 h

Exposure 1

Main characteristics
Frequency 1.9 GHz
Type
Charakteristic
  • guided field
Polarization
  • circular
Exposure duration continuous for 2 h
Modulation
Modulation type pulsed
Pulse width 6.7 ms
Duty cycle 33.5 %
Repetition frequency 50 Hz
Pulse type rectangular
Exposure setup
Exposure source
Chamber The exposure system consisted of six identical cylindrical waveguide applicators operating in T11 mode as described previously [McNamee et al., 2002].
Setup 10-ml aliquots of cell cultures were transferred to eight 60-mm Petri dishes, six of which were RF or sham exposed.
Sham exposure A sham exposure was conducted.
Additional info Two of the Petri dishes were kept in a tissue culture incubator, one for negative and one for positive control which was irradiated with 1.5 Gy 137Cs γ rays.
Parameters
Measurand Value Type Method Mass Remarks
SAR 0.1 W/kg mean - - -
SAR 0.26 W/kg mean - - -
SAR 0.92 W/kg mean - - -
SAR 2.4 W/kg mean - - -
SAR 10 W/kg mean - - -

Reference articles

  • McNamee JP et al. (2002): DNA damage and micronucleus induction in human leukocytes after acute in vitro exposure to a 1.9 GHz continuous-wave radiofrequency field.

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The study provides no evidence of a direct genotoxic effect in human blood after an acute (2h) exposure to radiofrequency fields.

Study character:

Study funded by

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