Study type: Medical/biological study (experimental study)

Immunotropic effects in cultured human blood mononuclear cells pre-exposed to low-level 1300 MHz pulse-modulated microwave field med./bio.

Published in: Electromagn Biol Med 2003; 22 (1): 1-13

Aim of study (acc. to author)

To determine potential immunomodulatory influences of pulse-modulated 1300 MHz microwave field on blood mononuclear cells (G0 phase cells) isolated from 16 healthy donors.



Exposure Parameters
Exposure 1: 1,300 MHz
Modulation type: pulsed
Exposure duration: continuous for 1 h

Exposure 1

Main characteristics
Frequency 1,300 MHz
Exposure duration continuous for 1 h
Additional info vertically polarised
Modulation type pulsed
Pulse width 5 µs
Repetition frequency 330 Hz
Exposure setup
Exposure source
Distance between exposed object and exposure source 1.5 m
Chamber 5.5 m long x 2.2 m wide x 2.1 m high
Setup A specimen of 3 ml of isolated PBMC was placed in a sterile tube.
Measurand Value Type Method Mass Remarks
power density 6,000 W/m² peak value measured - -
power density 10 W/m² mean measured - -
electric field strength 61.4 V/m mean measured - -
SAR 0.18 W/kg mean determined by power loss - -

Reference articles

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The results indicate that the exposure of the cells influenced the monocyte-dependent immunoregulatory mechanisms responsible for the initiation of immune response. The exposure further significantly increased the production of IL-1 and decreased the production of IL-1ra. The changed ratio of IL-1/IL-1ra resulted in an increased value of lymphocyte-monocyte cooperation index, which reflects the activation of immunogenic and proinflammatory functions of monocytes. The proliferative response of T lymphocytes to mitogens (PHA, concanavalin A) was not changed. But the exposure significantly increased the production of IL-10, the immunoregulatory lymphokine that is involved in the T cell-monocyte interaction. The immunstimulatory effects of the 1300 MHz fields seem to affect preferentially the immunogenic functions of monocytes and the increased production of IL-10 seems to be a secondary reaction of T cells in response to activated monocytes.

Study character:

Study funded by

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