Study type: Medical/biological study (experimental study)

Age-related effects on induction of DNA strand breaks by intermittent exposure to electromagnetic fields. med./bio.

Published in: Mech Ageing Dev 2003; 124 (7): 847-850

Aim of study (acc. to author)

This study was performed to investigate the effects of an intermittent electromagnetic field exposure on the DNA in relation to human fibroblasts from donors of different ages.

Background/further details

The human fibroblasts were maintained from six healthy donors in the age of 6, 14, 28, 43, 56 and 81 years.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: intermittent, 5 min on/10 min off for 1-24 h in 1 h steps.

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Waveform
Exposure duration intermittent, 5 min on/10 min off for 1-24 h in 1 h steps.
Exposure setup
Exposure source
Setup two four coil systems with 56 and 50 windings each of which was placed inside a µ-box; current in the bifilar coils could be switched parallel for field exposure or non parallel for sham exposure
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 1 mT unspecified unspecified - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

DNA strand breaks increased with exposure time, being largest at 15-19 hours. The DNA strand break levels declined thereafter, but did not return to basal levels.
Cell strains of different donors exhibited different basal levels, maxima and end levels of DNA strand breaks.
The fibroblasts from older individuals exhibited higher DNA strand break levels and they started to decline later than those from younger donors.
These findings suggest an age-related slow down of DNA repair efficiency of extremely low frequency electromagnetic field induced DNA strand breaks.

Study character:

Study funded by

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