Repetitive exposure to a 60-Hz time-varying magnetic field induces DNA double-strand breaks and apoptosis in human cells.
Published in: Biochem Biophys Res Commun 2010; 400 (4): 739-744
Aim of study (acc. to author)
continuous for up to 60 min
permanent magnets forming a plate with a diameter of 15 cm that could move up and down along a spindle so that the distance between the bottom and the magnets varied up to 12 cm; the maximum rotation speed was 1800 rpm; culture plates placed on the bottom of the exposure device which was placed inside an incubator
continuous for 30 min/day on 3 days
Main outcome of study (acc. to author)
Study funded by
Ministry of Knowledge Economy (MKE), Korea
Korea Research Institute of Chemical Technology (KRICT)
Yonsei University Research Fund, Korea
Lv Y et al.
Exposure to 50 Hz Extremely-Low-Frequency Magnetic Fields Induces No DNA Damage in Cells by Gamma H2AX Technology.
Sun C et al.
Ataxia telangiectasia mutated deficiency does not result in genetic susceptibility to 50 Hz magnetic fields exposure in mouse embryonic fibroblasts.
Song K et al.
A 60 Hz uniform electromagnetic field promotes human cell proliferation by decreasing intracellular reactive oxygen species levels.
Zhu K et al.
Extremely low frequency magnetic fields do not induce DNA damage in human lens epithelial cells in vitro.
Qiu L et al.
Exposure to a 50-Hz magnetic field induced ceramide generation in cultured cells.
Baharara J et al.
Extremely low frequency electromagnetic field sensitizes cisplatin-resistant human ovarian adenocarcinoma cells via P53 activation.
Mun GI et al.
Effects of 60-Hz magnetic fields on DNA damage responses in HT22 mouse hippocampal cell lines.
Yoon YJ et al.
Effects of 60-Hz Time-Varying Electric Fields on DNA Damage and Cell Viability Support Negligible Genotoxicity of the Electric Fields.
An GZ et al.
Effects of long-term 50 Hz power-line frequency electromagnetic field on cell behavior in Balb/c 3T3 cells.
Nakayama M et al.
DNA Strand Breaks in Fibroblasts Exposed to a 50-Hz Magnetic Field.
Kim J et al.
Time-varying magnetic fields of 60 Hz at 7 mT induce DNA double-strand breaks and activate DNA damage checkpoints without apoptosis.
Focke F et al.
DNA fragmentation in human fibroblasts under extremely low frequency electromagnetic field exposure.
Halicka HD et al.
Attenuation of constitutive ATM activation and H2AX phosphorylation in human leukemic TK6 cells by their exposure to static magnetic field.
Burdak-Rothkamm S et al.
DNA and chromosomal damage in response to intermittent extremely low-frequency magnetic fields.
Vijayalaxmi et al.
Genetic damage in mammalian somatic cells exposed to extremely low frequency electro-magnetic fields: a meta-analysis of data from 87 publications (1990-2007).
Schwenzer NF et al.
Detection of DNA double-strand breaks using gamma H2AX after MRI exposure at 3 Tesla: An in vitro study.
Luo Q et al.
50-Hertz electromagnetic fields induce gammaH2AX foci formation in mouse preimplantation embryos in vitro.
Nikolova T et al.
Electromagnetic fields affect transcript levels of apoptosis-related genes in embryonic stem cell-derived neural progenitor cells.
Crumpton MJ et al.
Are environmental electromagnetic fields genotoxic?
Ivancsits S et al.
Age-related effects on induction of DNA strand breaks by intermittent exposure to electromagnetic fields.
Robison JG et al.
Decreased DNA repair rates and protection from heat induced apoptosis mediated by electromagnetic field exposure.
Zhou J et al.
CREB DNA binding activation by a 50-Hz magnetic field in HL60 cells is dependent on extra- and intracellular Ca2+ but not PKA, PKC, ERK, or p38 MAPK.
Ivancsits S et al.
Induction of DNA strand breaks by intermittent exposure to extremely-low-frequency electromagnetic fields in human diploid fibroblasts.
Simko M et al.
Effects of 50 Hz EMF exposure on micronucleus formation and apoptosis in transformed and nontransformed human cell lines.