Induction of DNA strand breaks by intermittent exposure to extremely-low-frequency electromagnetic fields in human diploid fibroblasts. med./bio.

Aim of study (acc. to author)

Background/further details

Endpoint

• genotoxicity/mutation: DNA single-strand breaks/double-strand breaks

Exposure

• • 50/60 Hz
  • magnetic field

Extended view Compact view

Methods Endpoint/measurement parameters/methodology

• genotoxicity/mutation: DNA single-strand breaks/double-strand breaks (alkaline and neutral comet assay; "comet tail factor")

Main outcome of study (acc. to author)

Study funded by

• European Union (EU)/European Commission

Related articles

• Sun C et al. (2018): Ataxia telangiectasia mutated deficiency does not result in genetic susceptibility to 50 Hz magnetic fields exposure in mouse embryonic fibroblasts.
• Zhu K et al. (2016): Extremely low frequency magnetic fields do not induce DNA damage in human lens epithelial cells in vitro.
• Nakayama M et al. (2016): Evaluation of cell viability, DNA single-strand breaks, and nitric oxide production in LPS-stimulated macrophage RAW264 exposed to a 50-Hz magnetic field.
• Duan W et al. (2015): Comparison of the genotoxic effects induced by 50 Hz extremely low-frequency electromagnetic fields and 1800 MHz radiofrequency electromagnetic fields in GC-2 cells.
• Yoon HE et al. (2014): Increased gamma-H2AX by exposure to a 60-Hz magnetic fields combined with ionizing radiation, but not hydrogen peroxide, in non-tumorigenic human cell lines.
• Nakayama M et al. (2014): DNA Strand Breaks in Fibroblasts Exposed to a 50-Hz Magnetic Field.
• Kim J et al. (2010): Repetitive exposure to a 60-Hz time-varying magnetic field induces DNA double-strand breaks and apoptosis in human cells.
• Focke F et al. (2010): DNA fragmentation in human fibroblasts under extremely low frequency electromagnetic field exposure.
• Burdak-Rothkamm S et al. (2009): DNA and chromosomal damage in response to intermittent extremely low-frequency magnetic fields.
• Schwarz C et al. (2008): Radiofrequency electromagnetic fields (UMTS, 1,950 MHz) induce genotoxic effects in vitro in human fibroblasts but not in lymphocytes.
• Wahab MA et al. (2007): Elevated sister chromatid exchange frequencies in dividing human peripheral blood lymphocytes exposed to 50 Hz magnetic fields.
• Mairs RJ et al. (2007): Microsatellite analysis for determination of the mutagenicity of extremely low-frequency electromagnetic fields and ionising radiation in vitro.
• Federal Office for Radiation Protection (BfS) (2006): [Statement on the final report of the REFLEX research association (5th EU Framework Program)].
• Frahm J et al. (2006): Alteration in cellular functions in mouse macrophages after exposure to 50 Hz magnetic fields.
• Hone P et al. (2006): Chromatid damage in human lymphocytes is not affected by 50 Hz electromagnetic fields.
• Udroiu I et al. (2006): Clastogenicity and aneuploidy in newborn and adult mice exposed to 50 Hz magnetic fields.
• Villarini M et al. (2006): Effects of co-exposure to extremely low frequency (50 Hz) magnetic fields and xenobiotics determined in vitro by the alkaline comet assay.
• Scarfi MR et al. (2005): Evaluation of genotoxic effects in human fibroblasts after intermittent exposure to 50 Hz electromagnetic fields: a confirmatory study.
• Ivancsits S et al. (2005): Cell type-specific genotoxic effects of intermittent extremely low-frequency electromagnetic fields.
• Winker R et al. (2005): Chromosomal damage in human diploid fibroblasts by intermittent exposure to extremely low-frequency electromagnetic fields.
• Czyz J et al. (2004): Non-thermal effects of power-line magnetic fields (50 Hz) on gene expression levels of pluripotent embryonic stem cells-the role of tumour suppressor p53.
• Crumpton MJ et al. (2004): Are environmental electromagnetic fields genotoxic?
• Ivancsits S et al. (2003): Age-related effects on induction of DNA strand breaks by intermittent exposure to electromagnetic fields.
• Ivancsits S et al. (2003): Intermittent extremely low frequency electromagnetic fields cause DNA damage in a dose-dependent way.
• Pasquini R et al. (2003): Micronucleus induction in cells co-exposed in vitro to 50 Hz magnetic field and benzene, 1,4-benzenediol (hydroquinone) or 1,2,4-benzenetriol.