To study whether radiofrequency irradiation emitted by cellular phones is capable of inducing oxidative stress or affecting the response to oxidative stress in cultured mammalian cells.
To evaluate the effect of radiofrequency exposure on oxidative stress, the cells were stimulated with interferon-gamma and bacterial lipopolysaccharide prior to exposure. In some experiments interferon-gamma-primed cells were supplemented of L-NIO (an inhibitor of nitric oxide synthase), at the time of stimulation with lipopolysaccharide to allow assessment of the effects of nitric oxide.
| Frequency | 835.62 MHz |
|---|---|
| Type | |
| Exposure duration | continuous for 20 to 22 h |
| Modulation type | CW |
|---|---|
| Additional info |
| Exposure source |
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|---|---|
| Setup | Cells were exposed or sham exposed in T-75 flasks containing 40 ml of medium. |
| Frequency | 847.74 MHz |
|---|---|
| Type | |
| Exposure duration | continuous for 20 to 22 h |
| Exposure source |
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|---|
The data of these studies indicate that FMCW (frequency-modulated continuous wave)- and CDMA-modulated radiofrequency irradiation did not alter parameters indicative of oxidative stress in J774.16 cells.
FMCW- and CDMA-modulated fields did not alter the level of intracellular oxidants, accumulation of glutathione disulfide or induction of antioxidant defenses in interferon-gamma/lipopolysaccharide-stimulated cells.
Consistent with the lack of an effect on oxidative stress parameters, no change in toxicity was revealed in the cells after either optimal (2 µg/ml of bacterial lipopolysaccharide) (with or without inhibitors of nitric oxide synthase) or suboptimal (0.5 µg/ml of bacetrial lipopolysaccharide) stimulation.
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