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Medical/biological study (experimental study)

Effect of Exposure to the Edge Signal on Oxidative Stress in Brain Cell Models.

Published in: Radiat Res 2011; 175 (2): 225-230

Aim of study (acc. to author)

To study the effect of the EDGE signal on three human brain cell lines, SH-SY5Y, U87 and CHME5, used as models of neurons, astrocytes and microglia, respectively, as well as on primary cortical neuron cultures.
Background/further details: Cells were investigated at the end of the 24 h exposure or 24 h after the 1 h exposure. Rotenone treatment was used as a positive control.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 1,800 MHz
Modulation type: AM, pulsed
Exposure duration: continuous for 1 h or 24 h
Exposure 1
Main characteristics
Frequency 1,800 MHz
Type
Exposure duration continuous for 1 h or 24 h
Additional info EDGE-signal
Modulation
Modulation type AM, pulsed
Modulation frequency 8 Hz
Duty cycle 12.5 %
Repetition frequency 217 Hz
Pulse type rectangular
Additional info frame length: 4.61 ms
Exposure setup
Exposure source
Setup two hollow, rectangular waveguides (exposed and sham-exposed) placed inside an incubator; 6 petri dishes positioned inside the waveguide at the H-field maximum
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
SAR 2 W/kg - - - corresponding to the local ICNIRP exposure limit value for the public
SAR 10 W/kg - - - corresponding to the local ICNIRP exposure limit value for workers
Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated material:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The data indicate that exposure to the EDGE signal does not induce oxidative stress, irrespective of the conditions tested. The experiments do not support a specific sensitivity of primary cultures compared to the selected cell lines.
Study character:

Study funded by

  • Bouygues Telecom, France
  • Centre National de la Recherche Scientifique (CNRS; French National Center for Scientific Research), France
  • École Pratique des Hautes Etudes, France

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