Study type: Medical/biological study (experimental study)

Sinusoidal 50 Hz, 500 microT magnetic field has no acute effect on urinary 6-sulphatoxymelatonin in Wistar rats. med./bio.

Published in: Bioelectromagnetics 1995; 16 (6): 377-380

Aim of study (acc. to author)

To investigate the effect of a 50 Hz magnetic field (MF) exposure on melatonin production in rats.

Background/further details

6-sulphatoxymelatonin is the major metabolite of melatonin and can be determined easily non-invasively in excreted urine.
A total of 20 adult rats were used (10 male and 10 female, divided into 2 groups: magnetic field-exposed (500 µT) and sham exposed (5 µT, stray field)). A light (9 h)/dark (15 h) cycle was maintained (light on at 7 a.m./light off at 4 p.m.). Urine was collected twice a day (i.e. at the end of the dark phase and light phase, respectively) over a period of 5 consecutive days. The magnetic field was turned on at 7 a.m. on day 3 and turned off at 7 a.m. on day 4 (total magnetic field exposure time 24 h).

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: 24 h

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Waveform
Exposure duration 24 h
Exposure setup
Exposure source
  • pair of doublewound coils connected with a special AC generator
Chamber Metabolic cages/ 20 cm in diameter, 11 cm high.
Setup Cages kept in the center of the coils.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 5 µT effective value measured - cage located in the stray field
magnetic flux density 500 µT effective value measured - at the center of the cage

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • before exposure
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

No significant changes in the excretion of 6-sulphatoxymelatonin during or after magnetic field exposure could be observed.

Study character:

Study funded by

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