Study type: Medical/biological study (experimental study)

One week of exposure to 50 Hz, vertical magnetic field does not reduce urinary 6-sulphatoxymelatonin excretion of male wistar rats. med./bio.

Published in: Bioelectromagnetics 2002; 23 (3): 245-248

Aim of study (acc. to author)

To investigate the effect of a magnetic field (MF) exposure on 6-sulphatoxymelatonin urinary excretion in rats.

Background/further details

6-sulphatoxymelatonin is the major metabolite of melatonin and could easily non-invasive determined in excreted urine.
12 animals were used in this study (divided in to two groups/6 animals each). The groups were exposed to 100 µT and 50 µT flux density, respectively. After 2 weeks of acclimatisation to the light/dark cycle (12:12 h, light from 6.00 pm to 6.00 am) nocturnal urine was collected ad the end of the dark phase for four weeks. Animals were exposed to the magnetic field in the second week daily from 8.00 am to 4.00 pm.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Modulation type: CW
Exposure duration: 8 h/day, for 1 week

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Waveform
Polarization
Exposure duration 8 h/day, for 1 week
Additional info vertical
Modulation
Modulation type CW
Exposure setup
Exposure source
  • not specified
  • Mel-00011
Chamber plastic box 40x30x10cm
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 50 µT minimum measured - -
magnetic flux density 100 µT maximum measured - -

Reference articles

  • Bakos J et al. (1995): Sinusoidal 50 Hz, 500 microT magnetic field has no acute effect on urinary 6-sulphatoxymelatonin in Wistar rats.

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • before exposure
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

The excretion of the primary metabolite of melatonin in the urine, 6-sulphatoxymelatonin, was not statistically significant changed during or after magnetic field exposure.

Study character:

Study funded by

Related articles