Study type: Medical/biological study (experimental study)

Urinary 6-sulphatoxymelatonin excretion is increased in rats after 24 hours of exposure to vertical 50 Hz, 100 microT magnetic field. med./bio.

Published in: Bioelectromagnetics 1997; 18 (2): 190-192

Aim of study (acc. to author)

To investigate the effect of a 50 Hz magnetic field (MF) exposure on 6-sulphatoxymelatonin urinary excretion in rats. This study was a self-controlled experiment of a previous study (q.v. publication 1241). However, a magnetic flux density of 100 µT was applied in this study .

Background/further details

6-sulphatoxymelatonin is the major metabolite of melatonin and can be determined easily non-invasively in excreted urine.
A total of 10 adult, male rats was used (divided into 2 groups: MF-exposed (100 µT) and sham exposed (1 µT, stray field)). A light (9 h)/dark (15 h) cycle was maintained. (light on at 4 AM / light off at 7 PM). Urine was collected twice a day (i.e. at the end of the dark phase and light phase, respectively) over a period 5 consecutive days. The magnetic field was turned on at 7 AM on day 3 and turned off at 7 AM on day 4 (total MF exposure time 24 h).

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: 24 h

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Waveform
Exposure duration 24 h
Exposure setup
Exposure source
  • two double wound coil, inner diameter 42 cm, connected to an AC generator
Chamber metabolic cages
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 100 µT unspecified - unspecified vertical MF

Reference articles

  • Bakos J et al. (1995): Sinusoidal 50 Hz, 500 microT magnetic field has no acute effect on urinary 6-sulphatoxymelatonin in Wistar rats.

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • before exposure
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

One night after completion of MF exposure, rate of 6-sulphatoxymelatonin increased significantly compared with the rate on the day of exposure, but not significantly compared with the rates of the days before exposure.

Study character:

Study funded by

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