To determine if a weak alternating magnetic field (MF) exposure exerts tumor promoting or co-promoting effects in a rat breast cancer model. The chemical carcinogen DMBA was used to induce mammary tumors.
|Exposure duration||24 h/d, 7 d/week for 91 days|
|Chamber||6 exposure chamber (three for MF exposure and the other three for sham exposure); Acrylic cages/ 390 mm x 550 mm x 220 mm.|
|Setup||Each rat recieved 5 mg of dimethylbenz(a)anthracene dissolved in sesame oil (1ml/rat) and was placed into its home cage into the exposure chamber.|
Magnetic field exposed rats exhibited statistically significantly more tumors than sham-exposed animals. The tumor size as estimated by palpation was significantly larger in exposed animals 13 weeks after DMBA application. However, the mean number of tumors per tumor-bearing rat did not differ. The results of this study demonstrate that MF exposure in this DMBA rat model promotes the growth and increases the inzidence of mammary tumors.