Study type: Medical/biological study (experimental study)

Electromagnetic fields do not affect bone micro-architecture in osteoporotic rats. med./bio.

Published in: Bone Joint Res 2014; 3 (7): 230-235

Aim of study (acc. to author)

The effects of exposure of osteoporotic and healthy rats to a 50 Hz magnetic field on bone micro-architecture and fracture healing should be investigated.

Background/further details

15 young rats were divided into two groups: 1) bilateral ovariectomy (to induce osteoporosis) (n=8) and 2) sham ovariectomy (n=7). 19 days after (sham) ovariectomy, a bilateral fibula fracture was generated in all rats. 2 days after fracture generation, exposure to the magnetic field started. Only one leg was exposed, respectively, the other leg was wrapped in copper foil for protection against the field and served as the control.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: continuous for 3 h/day on 5 days/week for 6 weeks

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Waveform
Exposure duration continuous for 3 h/day on 5 days/week for 6 weeks
Exposure setup
Exposure source
Setup During exposure, rats were placed in a custom-made harness; coil was placed at one hind leg from the knee to the ankle joint; the other hind leg (control) was wrapped in µ-copper foil for protection against the magnetic field
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 2 mT - - - -

Reference articles

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • before exposure
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

No significant differences were found between exposed and non-exposed (control) bones.
The authors conclude that the results give no indications for an effect of exposure of osteoporotic and healthy rats to a 50 Hz magnetic field on bone micro-architecture and fracture healing.

Study character:

Study funded by

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