Study type: Medical/biological study (experimental study)

The risk of lymphoma in AKR/J mice does not rise with chronic exposure to 50 Hz magnetic fields (1 microT and 100 microT). med./bio.

Published in: Radiat Res 2004; 162 (2): 194-200

Aim of study (acc. to author)

To study whether 50 Hz magnetic field exposure influences lymphoma development in a mouse strain that is genetically predisposed to this disease.

Background/further details

The AKR/J mice genome carries a virus, which leads within one year to spontaneous development of thymic lymphoblastic lymphoma.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: continuous for 38 weeks
Exposure 2: 50 Hz
Exposure duration: continuous for 38 weeks

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Waveform
Exposure duration continuous for 38 weeks
Exposure setup
Exposure source
  • coil systems consisting of 2 outer and inner coils arranged in Merritt configuration
Setup 10 cages with 80 animals were placed in one coil system
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 1 µT unspecified measured - -

Exposure 2

Main characteristics
Frequency 50 Hz
Type
Waveform
Exposure duration continuous for 38 weeks
Exposure setup
Exposure source
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 100 µT unspecified measured - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

There was no effect of magnetic field exposure on body weight gain or survival rate. Lymphoma incidence did not differ between exposed and sham-exposed mice. These findings do not support the hypothesis that chronic exposure to 50 Hz magnetic fields is a significant risk factor for developing hematopoietic malignancy.

Study character:

Study funded by

Related articles