Study type: Medical/biological study (experimental study)

50 Hz magnetic fields of 1 mT do not promote lymphoma development in AKR/J mice. med./bio.

Published in: Radiat Res 2006; 165 (3): 343-349

Aim of study (acc. to author)

To study whether chronic, high-level (1 mT) magnetic field exposure had an influence on lymphoma development in a mouse strain that is genetically predisposed to this disease.

Background/further details

The AKR/J mice genome carries a virus, which leads within one year to spontaneous development of thymic lymphoblastic lymphoma.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: continuous for 24 h/day, 7 days a week for 32 weeks or until exitus
Exposure 2: 50 Hz
Exposure duration: only during the night for 12 h/day, 7 days a week for 32 weeks or until exitus

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Waveform
Exposure duration continuous for 24 h/day, 7 days a week for 32 weeks or until exitus
Exposure setup
Exposure source
Setup Ten randomly chosen cages (8 animals/cage; 40 x 25 x 30 cm³ lxwxh) were placed in one coil system of two outer and two inner rectangular coils. Two coil systems with anti-parallel wiring were used for sham exposure where as other two were designed to produce magnetic fields only during the dark phases. All coil systems were located in the same room (220 m²).
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 1 mT unspecified measured - -

Exposure 2

Main characteristics
Frequency 50 Hz
Type
Waveform
Exposure duration only during the night for 12 h/day, 7 days a week for 32 weeks or until exitus
Exposure setup
Exposure source
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 1 mT unspecified measured - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

Exposure did not affect survival time, body weight, lymphoma development or hematological parameters. The results do not support the hypothesis that exposure to sinusoidal 50 Hz magnetic fields is a significant risk factor for hematopoietic diseases, even at this relatively high exposure level.

Study character:

Study funded by

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