Study type: Medical/biological study (experimental study)

In vitro assessment of clastogenicity of mobile-phone radiation (835 MHz) using the alkaline comet assay and chromosomal aberration test. med./bio.

Published in: Environ Toxicol 2008; 23 (3): 319-327

Aim of study (acc. to author)

To study two kinds of cytogenetic endpoints (alkaline comet assay and chromosome aberration test) on mammalian cells exposed to 835 MHz radiofrequency electromagnetic fields alone and in combination with known model clastogens (cyclophosphamide and ethylmethanesulfonate).

Endpoint

Exposure

Exposure Parameters
Exposure 1: 835 MHz
Exposure duration: continuous for up to 48 h

Exposure 1

Main characteristics
Frequency 835 MHz
Type
Charakteristic
  • guided field
Exposure duration continuous for up to 48 h
Exposure setup
Exposure source
Chamber The TEM exposure system was placed inside a CO2 incubator at 37°C.
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
SAR 4 W/kg - measured - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The data suggest that in the chromosome aberration assay the 835 MHz radiofrequency electromagnetic field did not induce any direct clastogenic effect alone or in combination with the model clastogenic agents, while in the alkaline comet assay the presence of an applied radiofrequency electromagnetic field statistically significantly enhanced the clastogenic activity of model clastogens.
Thus, the authors cannot exclude any possibility of an increased risk of genetic damage, with important implications for the possible health effects of exposure to 835 MHz electromagnetic fields.

Study character:

Study funded by

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