Study type: Medical/biological study (experimental study)

954 MHz microwaves enhance the mutagenic properties of mitomycin C. med./bio.

Published in: Environ Mol Mutagen 1996; 28 (1): 26-30

Aim of study (acc. to author)

To study the combined effects of microwaves of a GSM mobile telephone frequency and the chemical mutagen mitomycin C (mitomycin C (MMC) is a well-known sister chromatid exchange inducer).

Endpoint

Exposure

Exposure Parameters
Exposure 1: 954 MHz
Modulation type: pulsed
Exposure duration: continuous for 2 h

Exposure 1

Main characteristics
Frequency 954 MHz
Type
Exposure duration continuous for 2 h
Modulation
Modulation type pulsed
Additional info

GSM signal

Exposure setup
Exposure source
Distance between exposed object and exposure source 5 cm
Setup Blood samples of 5 ml in test tubes were placed in a cooled box and exposed at 5 cm to a field from a GSM base station emitted by an indoor antenna having the same characteristics as the outdoor antenna to which it was connected.
Additional info Six combinations of in vitro exposure of cells were studied: no exposure (control), exposure to MW before cultivation, exposure to two concentrations of mitomycin C (MMC) during cultivation, exposure to MW followed by cultivation in the presence of two concentrations of MMC.
Parameters
Measurand Value Type Method Mass Remarks
power 15 W - - - -
electric field strength 49 V/m - measured - 46-51 V/m
SAR 1.5 W/kg - calculated - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

Exposure of the cells to the microwaves alone does not increase the frequency of sister chromatid exchanges compared to the mean value in the nonexposed controls. Exposure to MMC alone results in a dose-dependent increase in sister chromatid exchange frequency. The response of the lymphocytes to the MMC is statistically higher when the cells were previously exposed to the microwaves (a highly reproducible synergistic effect was observed).
The cell kinetics were significantly changed (lower proliferation) by addition of the mutagen. The cell kinetics were not influenced by previous radiation to the microwaves. The cell kinetics were not changed by the microwaves alone.

Study character:

Study funded by

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