Study type: Medical/biological study (experimental study)

The effects of radiofrequency on skin: Experimental study med./bio.

Published in: Lasers Surg Med 2008; 40 (2): 76-82

Aim of study (acc. to author)

This study should investigate whether the exposure to radiofrequency can evoke changes in the skin of guinea pigs.

Background/further details

Eighteen tricolour guinea pigs (nine males and nine females) were used, six in the control group and 12 in the exposure group. The animals were shaved before exposure. Punch biopsies of the skin were taken within 48 to 72 hours following each session, and 2 months following the final treatment.



Exposure Parameters
Exposure 1: 4–8 MHz
Modulation type: pulsed
Exposure duration: repeated exposure, 6 min/week, for 6 weeks

Exposure 1

Main characteristics
Frequency 4–8 MHz
Exposure duration repeated exposure, 6 min/week, for 6 weeks
Additional info "interwoven bipolar RF waves from 4 to 8 MHz"
Modulation type pulsed
Pulse width 3 ms
Exposure setup
Exposure source
  • Thermafine Lift device
Setup A 1-cm² tip was used, including an air-cooling system. The applicator was moved across the shaved skin until the surface temperature of the treated area (taken with an RS Mini IR LASER Thermometer) rose by 3 to 5°C.

No parameters are specified for this exposure.

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

A slight erythema accompanied by an increase in local temperature (between 3 and 5 °C) was found after each exposure. The most relevant changes were seen in the papillary region of the dermis which underwent an expansion due to oedema and congestion in the first half of the experiment. An increase in cellularity and the accumulation of intercellular substance followed. Likewise, the content of collagen, elastic fibres and mucopolysaccharides increased.

Study character:

Study funded by

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