Study type: Medical/biological study (experimental study)

Mobile phone radiation might alter protein expression in human skin med./bio.

Published in: BMC Genomics 2008; 9: 77

Aim of study (acc. to author)

This study was conducted to determine whether a local exposure of human skin to radiofrequency electromagnetic field induces any changes in protein expression and whether it is possible to find common proteins that respond to radiofrequency electromagnetic field in all volunteers.

Background/further details

A small area of forearm's skin in 10 female volunteers was exposed to radiofrequency electromagnetic field at a specific absorption rate of 1.3 W/kg. This specific absorption rate is below the ICNIRP safety guidelines (2.0 W/kg). Punch biopsies were collected from exposed and sham exposed areas of the skin.



Exposure Parameters
Exposure 1: 900 MHz
Modulation type: pulsed
Exposure duration: continuous for 1 h

Exposure 1

Main characteristics
Frequency 900 MHz
Exposure duration continuous for 1 h
Modulation type pulsed
Additional info


Exposure setup
Exposure source
Chamber The experimental setup has been described in detail elsewhere [Toivonen et al., 2007].
Setup The GSM phone was computer controlled.
Sham exposure A sham exposure was conducted.
Additional info A small area of the right forearm was irradiated, and the other, non-irradiated forearm was used as sham control.
Measurand Value Type Method Mass Remarks
SAR 1.3 W/kg - - - in the skin

Reference articles

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

Eight differentially expressed proteins were identified. Two proteins were present in all 10 volunteers thus showing that it is possible to find common, radiofrequency electromagnetic field responding proteins among the all volunteers.
These results suggest that human skin might respond to radiofrequency electromagnetic field and change protein expression profile. Whether these changes might have impact on skin physiology has to be further investigated.

Study character:

Study funded by

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