Study type: Medical/biological study (experimental study)

Effect of GSM-900 and -1800 signals on the skin of hairless rats. III: Expression of heat shock proteins. med./bio.

Published in: Int J Radiat Biol 2008; 84 (1): 61-68

Aim of study (acc. to author)

This in vivo study was performed to study the effects of single or repeated radio frequency exposure (900 and 1800 MHz GSM) on rat skin.

Background/further details

As marker of stress response due to the radiofrequency exposure the heat shock proteins Hsp25, Hsp70, and Hsc70 were measured.
The hairless skin of ten week-old female rats received local exposure. UV-B radiated rats served as positive controls. Additionally, sham exposure and cage control werde performed. Each experimental group consisted of eight animals.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 900 MHz
Modulation type: pulsed
Exposure duration: continuous for 2 h
Exposure 2: 1,800 MHz
Modulation type: pulsed
Exposure duration: continuous for 2 h
Exposure 3: 900 MHz
Modulation type: pulsed
Exposure duration: repeated daily exposure, 2 h/day, 5 days/week, for 12 weeks
Exposure 4: 1,800 MHz
Modulation type: pulsed
Exposure duration: repeated daily exposure, 2 h/day, 5 days/week, for 12 weeks

Exposure 1

Main characteristics
Frequency 900 MHz
Type
Exposure duration continuous for 2 h
Modulation
Modulation type pulsed
Additional info

GSM

Exposure setup
Exposure source
Setup Rats were placed in rockets and exposed using a 1 x 3 cm loop antenna [Leveque et al., 2004] positioned on the right part of their back.
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
SAR 5.8 W/kg mean measured - ± 0.4 W/kg

Exposure 2

Main characteristics
Frequency 1,800 MHz
Type
Exposure duration continuous for 2 h
Modulation
Modulation type pulsed
Additional info

GSM

Exposure setup
Exposure source
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
SAR 4.8 W/kg mean measured - ± 0.4 W/kg

Exposure 3

Main characteristics
Frequency 900 MHz
Type
Exposure duration repeated daily exposure, 2 h/day, 5 days/week, for 12 weeks
Modulation
Modulation type pulsed
Additional info

GSM

Exposure setup
Exposure source
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
SAR 5.8 W/kg mean measured - ± 0.4 W/kg
SAR 2.9 W/kg mean measured - -

Exposure 4

Main characteristics
Frequency 1,800 MHz
Type
Exposure duration repeated daily exposure, 2 h/day, 5 days/week, for 12 weeks
Modulation
Modulation type pulsed
Additional info

GSM

Exposure setup
Exposure source
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
SAR 4.8 W/kg mean measured - ± 0.4 W/kg
SAR 2.4 W/kg mean measured - -

Reference articles

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated material:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

Neither the single nor the repeated radio frequency exposures altered the heat shock protein expression in rat skin, irrespective of the GSM signal (900 MHz or 1800 MHz) or specific absorption rates considered.

Study character:

Study funded by

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