Study type: Medical/biological study (experimental study)

Effects of exposure to 1.8 GHz radiofrequency field on the expression of Hsps and phosphorylation of MAPKs in human lens epithelial cells. med./bio.

Published in: Cell Res 2008; 18 (12): 1233-1235

Aim of study (acc. to author)

To study whether exposure to 1.8 GHz radiofrequency can influence the cellular physiology of the lens epithelial cells, the expression of heat shock proteins and the activation of mitogen-activated protein kinases in these cells after exposure were evaluated.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 1.8 GHz
Exposure duration: up to 2 h
  • SAR: 1 W/kg average over time (1, 2, 3, 4 W/kg)

Exposure 1

Main characteristics
Frequency 1.8 GHz
Type
Exposure duration up to 2 h
Exposure setup
Exposure source
  • not specified
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
SAR 1 W/kg average over time - - 1, 2, 3, 4 W/kg

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

1.8 GHz radiofrequency exposure induced the up-regulation of Hsp27 und Hsp70 when SAR value was equal or greater than 2 W/kg.
The data showed that ERK-1/2 was markedly activated as early as 5 minutes after radiofrequency exposure; the activation peaked at 30 minutes and lasted up to 2 h after exposure. Phosphorylation of JNK-1/2 was detected at 2 h after irradiation, while p38 MAPK activation was not found.
Phosphorylation of ERK-1/2 and JNK-1/2 together with Hsp up-regulation suggest that nonthermal radiofrequency exposure can induce the stress response in human lens epithelial cells.

Study character:

Study funded by

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