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To study whether exposure to 1.8 GHz radiofrequency can influence the cellular physiology of the lens epithelial cells, the expression of heat shock proteins and the activation of mitogen-activated protein kinases in these cells after exposure were evaluated.
ばく露時間: up to 2 h
|ばく露時間||up to 2 h|
|Sham exposure||A sham exposure was conducted.|
|SAR||1 W/kg||average over time||-||-||1, 2, 3, 4 W/kg|
1.8 GHz radiofrequency exposure induced the up-regulation of Hsp27 und Hsp70 when SAR value was equal or greater than 2 W/kg.
The data showed that ERK-1/2 was markedly activated as early as 5 minutes after radiofrequency exposure; the activation peaked at 30 minutes and lasted up to 2 h after exposure. Phosphorylation of JNK-1/2 was detected at 2 h after irradiation, while p38 MAPK activation was not found.
Phosphorylation of ERK-1/2 and JNK-1/2 together with Hsp up-regulation suggest that nonthermal radiofrequency exposure can induce the stress response in human lens epithelial cells.