研究のタイプ: 医学/生物学の研究 (experimental study)

[ヒトの水晶体上皮細胞におけるHspの発現およびMAPKのリン酸化に対する1.8GHz無線周波電磁界ばく露の影響] med./bio.

Effects of exposure to 1.8 GHz radiofrequency field on the expression of Hsps and phosphorylation of MAPKs in human lens epithelial cells.

掲載誌: Cell Res 2008; 18 (12): 1233-1235

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研究目的(著者による)

To study whether exposure to 1.8 GHz radiofrequency can influence the cellular physiology of the lens epithelial cells, the expression of heat shock proteins and the activation of mitogen-activated protein kinases in these cells after exposure were evaluated.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 1.8 GHz
ばく露時間: up to 2 h
  • SAR: 1 W/kg average over time (1, 2, 3, 4 W/kg)

ばく露1

主たる特性
周波数 1.8 GHz
タイプ
  • electromagnetic field
ばく露時間 up to 2 h
ばく露装置
ばく露の発生源/構造
  • 詳細不明
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
SAR 1 W/kg average over time - - 1, 2, 3, 4 W/kg

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

1.8 GHz radiofrequency exposure induced the up-regulation of Hsp27 und Hsp70 when SAR value was equal or greater than 2 W/kg.
The data showed that ERK-1/2 was markedly activated as early as 5 minutes after radiofrequency exposure; the activation peaked at 30 minutes and lasted up to 2 h after exposure. Phosphorylation of JNK-1/2 was detected at 2 h after irradiation, while p38 MAPK activation was not found.
Phosphorylation of ERK-1/2 and JNK-1/2 together with Hsp up-regulation suggest that nonthermal radiofrequency exposure can induce the stress response in human lens epithelial cells.

研究の種別:

研究助成

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