Study type: Medical/biological study (experimental study)

Influence of electromagnetic fields on bone fracture in rats: role of CAPE. med./bio.

Published in: Biomed Environ Sci 2009; 22 (2): 157-160

Aim of study (acc. to author)

To study the effects of exposure to 900 MHz and 1800 MHz on bone fracture and the role of CAPE (caffeic acid phenethyl ester) on the induced changes.

Background/further details

CAPE is one of the major components of honeybee propolis. It has been used in folk medicine for many years in Middle East countries. CAPE was found to be a potent free radical scavenger and antioxidant.
48 rats were divided into five groups: 1) sham exposure (n=10); 2) 900 MHz exposure (n=8); 3) treatment with CAPE before 900 MHZ exposure (n=10) ; 4) 1800 MHz exposure (n=10); 5) treatment with CAPE before 1800 MHz exposure (n=10). At the end of the experiment, the animals were sacrificed and the left femur was removed.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 900 MHz
Modulation type: CW
Exposure duration: continuous for 30 min/day, for 28 days
Exposure 2: 1,800 MHz
Modulation type: CW
Exposure duration: continuous for 30 min/day, for 28 days

Exposure 1

Main characteristics
Frequency 900 MHz
Type
Exposure duration continuous for 30 min/day, for 28 days
Additional info rats were divided into two groups: i) without CAPE treatment ii) with 10 µmol/kg CAPE treatment
Modulation
Modulation type CW
Exposure setup
Exposure source
Setup rats placed above the antenna in 12 cm long plastic tube cages with a diameter of 5.5 cm
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
power 2 W - - - -
power density 1 mW/cm² average over time measured - -
SAR 2 W/kg - - whole body -

Exposure 2

Main characteristics
Frequency 1,800 MHz
Type
Exposure duration continuous for 30 min/day, for 28 days
Additional info rats were divided into two groups: i) without CAPE treatment ii) with 0.569 mg CAPE treatment
Modulation
Modulation type CW
Exposure setup
Exposure source
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
power density 1 mW/cm² average over time measured - -
SAR 2 W/kg - - whole body -
power 1.5 W - - - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The exposure groups that were pretreated with CAPE had significantly higher values in breaking force, bending strength, and total fracture engery of the femur compared to the exposure groups without CAPE pretreatment. However, all exposure and CAPE treatment groups (2-5) showed decreased values for all three parameters compared to the sham exposed group (1).
Both radiofrequency electromagnetic fields and CAPE had effects on bones.

Study character:

Study funded by

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