研究のタイプ: 医学/生物学の研究 (experimental study)

[ラットの骨折に対する電磁界の影響:CAPEの役割] med./bio.

Influence of electromagnetic fields on bone fracture in rats: role of CAPE.

掲載誌: Biomed Environ Sci 2009; 22 (2): 157-160

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研究目的(著者による)

To study the effects of exposure to 900 MHz and 1800 MHz on bone fracture and the role of CAPE (caffeic acid phenethyl ester) on the induced changes.

詳細情報

CAPE is one of the major components of honeybee propolis. It has been used in folk medicine for many years in Middle East countries. CAPE was found to be a potent free radical scavenger and antioxidant.
48 rats were divided into five groups: 1) sham exposure (n=10); 2) 900 MHz exposure (n=8); 3) treatment with CAPE before 900 MHZ exposure (n=10) ; 4) 1800 MHz exposure (n=10); 5) treatment with CAPE before 1800 MHz exposure (n=10). At the end of the experiment, the animals were sacrificed and the left femur was removed.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 900 MHz
Modulation type: CW
ばく露時間: continuous for 30 min/day, for 28 days
ばく露2: 1,800 MHz
Modulation type: CW
ばく露時間: continuous for 30 min/day, for 28 days

ばく露1

主たる特性
周波数 900 MHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 30 min/day, for 28 days
Additional information rats were divided into two groups: i) without CAPE treatment ii) with 10 µmol/kg CAPE treatment
Modulation
Modulation type CW
ばく露装置
ばく露の発生源/構造
  • half wave dipole antenna
ばく露装置の詳細 rats placed above the antenna in 12 cm long plastic tube cages with a diameter of 5.5 cm
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
電力 2 W - - - -
電力密度 1 mW/cm² average over time 測定値 - -
SAR 2 W/kg - - whole body -

ばく露2

主たる特性
周波数 1,800 MHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 30 min/day, for 28 days
Additional information rats were divided into two groups: i) without CAPE treatment ii) with 0.569 mg CAPE treatment
Modulation
Modulation type CW
ばく露装置
ばく露の発生源/構造
  • E1と同じ装置
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
電力密度 1 mW/cm² average over time 測定値 - -
SAR 2 W/kg - - whole body -
電力 1.5 W - - - -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

The exposure groups that were pretreated with CAPE had significantly higher values in breaking force, bending strength, and total fracture engery of the femur compared to the exposure groups without CAPE pretreatment. However, all exposure and CAPE treatment groups (2-5) showed decreased values for all three parameters compared to the sham exposed group (1).
Both radiofrequency electromagnetic fields and CAPE had effects on bones.

研究の種別:

研究助成

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