Study type: Medical/biological study (experimental study)

The protective effect of caffeic acid phenethyl ester (CAPE) on oxidative stress in rat liver exposed to the 900 MHz electromagnetic field. med./bio.

Published in: Toxicol Ind Health 2009; 25 (6): 429-434

Aim of study (acc. to author)

To study the possible protective effects of caffeic acid phenethyl ester (CAPE) on lipid peroxidation and the antioxidant enzyme activities in rat liver exposed to 900 MHz electromagnetic fields.

Background/further details

Male rats were divided into three groups (each n=10): 1) control group; 2) exposure group; 3) exposure + CAPE. CAPE was injected 30 days before exposure.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 900 MHz
Modulation type: CW
Exposure duration: continuous for 1 h/day for 30 days

Exposure 1

Main characteristics
Frequency 900 MHz
Type
Exposure duration continuous for 1 h/day for 30 days
Additional info rats were divided into three groups: i) sham control ii) RF exposure iii) CAPE + RF exposure
Modulation
Modulation type CW
Exposure setup
Exposure source
Setup rats kept in 12 cm long plastic tube cages with a diameter of 5.5 cm; cage positioned directly above the antenna
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
power 2 W peak value - - -
power density 1.04 W/cm² average over time measured - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The enzyme activity of xanthine oxidase, catalase and the levels of lipid peroxidation were significantly increased in the exposure group compared to the control group, although these parameters were significantly decreased in the "CAPE + exposure" group (compared to the exposure group; similar values as the control group). The superoxide dismutase enzyme activity and glutathione peroxidase activity significantly decreased in the exposure group compared with the control group, although their levels were significantly increased in the "CAPE + exposure" group (compared to the exposure group; similar values as the control group).
The authors conclude that CAPE may prevent the electromagnetic field induced oxidative changes in liver by strengthening the antioxidant defense system (by reducing reactive oxygen species and increasing antioxidant enzyme activities).

Study character:

Study funded by

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