Study type: Medical/biological study (experimental study)

Spindle disturbances in human-hamster hybrid (A(L)) cells induced by the electrical component of the mobile communication frequency range signal. med./bio.

Published in: Bioelectromagnetics 2011; 32 (4): 291-301

Aim of study (acc. to author)

To study whether either the electrical (E field) and/or the magnetic field (H field) component of an electromagnetic field at 900 MHz can be associated with the effectiveness of the spindle-disturbing potential (as shown in a previous study, see Schrader et al. 2008).

Background/further details

Three experiments were performed: Two experiments were performed at room temperature (20-22°C) and a third experiment at 37°C.



Exposure Parameters
Exposure 1: 900 MHz
Exposure duration: continuous for 0.5 h
  • power: 200 mW effective value
  • SAR: 10.7 mW/kg minimum (calculated 0.1 mm above and in the center of the slide)
  • SAR: 17.2 mW/kg maximum (calculated 0.1 mm above and in the center of the slide)

General information

Experiments were conducted in six groups: i) E = 90 V/m, E-field and H-field, unmodulated travelling wave ii) E = 45 V/m, E-field and H-field, unmodulated travelling wave iii) E = 90 V/m, E-field only, standing wave iv) E < 0.1 V/m, H-field only, standing wave v) E = 90 V/m, E-field and H-field, amplitude modulated travelling wave (GSM signal used) vi) sham exposure

Exposure 1

Main characteristics
Frequency 900 MHz
Exposure duration continuous for 0.5 h
Exposure setup
Exposure source
Setup by placing a movable short cut at the end of the waveguide the E- fields and H-fields were spatially separated in the waveguide when producing a standing wave; cells fixed in a monolayer on a microscope slide, positioned inside the waveguide below the septum
Sham exposure A sham exposure was conducted.
Measurand Value Type Method Mass Remarks
power 200 mW effective value measured - -
SAR 10.7 mW/kg minimum calculated - calculated 0.1 mm above and in the center of the slide
SAR 17.2 mW/kg maximum calculated - calculated 0.1 mm above and in the center of the slide

Reference articles

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The data showed that only cells exposed to the magnetic field component of the electromagnetic field were not different from the control. The results have confirmed the spindle-acting potential of a radiofrequency exposure at 835 MHz in human-hamster hybrid cells, which was reported for a 0.5 h exposure at field strengths from 45 to 90 V/m (see Schrader et al. 2008 and Schmid and Schrader 2007). Moreover, both the earlier and present data sets have shown that the fractions of anaphases and telophases with spindle disturbances are twice as high at 90 V/m than at 45 V/m. The findings were independent of the exposure temperatures at room temperature or 37°C.
The data indicate that an exposure of cells to an electromagnetic field at electric field strengths of 45 and 90 V/m, as well as to the separated E component of the electromagnetic field, induce significant spindle disturbances in anaphases and telophases of the cell cycle.

Study character:

Study funded by

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