Study type: Medical/biological study (experimental study)

Effect of exposure to extremely low electro-magnetic field during prenatal period on mice spleen. med./bio.

Published in: Indian J Exp Biol 2011; 49 (8): 634-638

Aim of study (acc. to author)

To study the effects of extremely low frequency magnetic fields on the embryogenesis of mice, particularly on the development of the spleen.

Background/further details

48 pregnant mice were divided into six groups (each group n=8): 1) control group, 2) sham exposed group, 3) - 6) exposure groups starting with exposure on different days of gestation (1-5, 6-10, 11-15, 16-20).

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: continuous for 10 h/day on 5 days

General information

Mice were divided into six groups: i) control ii) sham exposure iii) five days of EMF exposure starting on day 1 of gestation iv) five days of EMF exposure starting on day 6 of gestation v) five days of EMF exposure starting on day 11 of gestation vi) five days of EMF exposure starting on day 16 of gestation

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Exposure duration continuous for 10 h/day on 5 days
Additional info it can not be extracted from the article whether the magnetic field was sinusoidal or pulsed, the author gives contradictory information
Exposure setup
Exposure source
Sham exposure A sham exposure was conducted.
Additional info it can not be extracted from the article which sort of coil was used: a Helmholtz coil or a solenoid; the authors mention a Helmholtz coil but describes a solenoid (a 50 Hz sinusoidal oscillating ELF-EMF was produced by a 380 round turn coil twisted around a cylinder - 19 cm diameter and 15.5 cm length - and containing a chamber to house mice in the center of the cylinder)
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 6 mT - measured - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

Total body weight of newborns, the volume of spleen, and the number of megakaryocytes decreased following the exposure to extremely low frequency electromagnetic fields. The complete period of gestation was sensitive to exposure and the initial days were more sensitive, i.e. the effects were more pronounced.

Study character:

Study funded by

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